{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:27:18Z","timestamp":1788812838808,"version":"build-2803163510"},"reference-count":41,"publisher":"Microbiology Society","issue":"4","funder":[{"DOI":"10.13039\/501100004035","name":"Jordan University of Science and Technology","doi-asserted-by":"crossref","award":["20150257"],"award-info":[{"award-number":["20150257"]}],"id":[{"id":"10.13039\/501100004035","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Growing concern about the increasing frequency of resistance of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">Helicobacter pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> to the available antimicrobial agents worldwide has encouraged the search for new strategies in treating and eradicating <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> infections. Endoscopic blue-light therapy has been used in patients with <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> gastritis with limited success due to subsequent repopulation with <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic>. Clinical trials using Curcumin could not eradicate infection either.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim.<\/jats:bold> We studied the effect of blue light emitting diodes (LEDs) in conjunction with Curcumin on <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic>, since this has not been previously reported.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> We examined the effect of Curcumin with and without irradiation with blue LEDs on the viability of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> and four key factors important for colonization and establishment of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> infection, namely urease production, motility, adhesion and biofilm formation.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> We found that a combination of Curcumin and blue LEDs caused significant reductions in viability, urease production, motility, haemagglutination activity, as well as increased disruption of mature preformed biofilms of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic>, in comparison to Curcumin alone (<jats:italic>P<\/jats:italic>&lt;0.0001), at sublethal concentrations of Curcumin.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Targeting the virulence factors of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> with blue LED photoactivated Curcumin would theoretically cripple this pathogen from colonizing and causing tissue damage and perhaps overcome the problem of repopulation with <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3833\" xlink:type=\"simple\">H. pylori<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> that often occurs following endoscopic blue-light therapy.<\/jats:p>","DOI":"10.1099\/jmm.0.001168","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T16:13:27Z","timestamp":1582647207000},"page":"617-624","source":"Crossref","is-referenced-by-count":23,"title":["Blue light emitting diodes enhance the antivirulence effects of Curcumin 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