{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:40:08Z","timestamp":1791319208302,"version":"4.3.1"},"reference-count":17,"publisher":"Microbiology Society","issue":"7","funder":[{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"crossref","award":["UBACyT 20020130100167BA"],"award-info":[{"award-number":["UBACyT 20020130100167BA"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"\n Introduction.<\/jats:bold> The therapeutic options to treat \n \n Acinetobacter baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> infections are very limited.<\/jats:p>\n \n Aim.<\/jats:bold> Our aim was to evaluate the activity of sulbactam combined directly with avibactam or the ampicillin-sulbactam\/ceftazidime-avibactam combination against extensively drug-resistant \n \n A. baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolates.<\/jats:p>\n \n Methodology.<\/jats:bold> Extensively drug-resistant \n \n A. baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolates (n<\/jats:italic>=127) collected at several South American hospitals were studied. Synergy with the sulbactam\/avibactam combination was assessed in all isolates using the agar dilution method. Avibactam was used at a fixed concentration of 4 mg l\u22121<\/jats:sup>. A disc diffusion synergy test was also performed. Synergy by a time-kill experiment was performed in a selected isolate.<\/jats:p>\n \n Results.<\/jats:bold> Synergy with sulbactam\/avibactam was demonstrated in 124 isolates and it showed MIC values \u22644 mg l\u22121<\/jats:sup>. This synergy was not detected in the three New Delhi metallo-\u03b2-lactamase-harbouring isolates. Similar results were observed with the disc diffusion synergy test of ampicillin-sulbactam\/ceftazidime-avibactam. In the time-kill experiments, sulbactam\/avibactam showed a rapid synergistic and bactericidal activity in ampicillin-sulbactam-resistant isolates.<\/jats:p>\n \n Conclusions.<\/jats:bold> This study demonstrated that the sulbactam\/avibactam combination displayed synergistic activity against \n \n A. baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolates. This synergy was observed when both inhibitors were also used as part of the commercially available combinations: ampicillin-sulbactam and ceftazidime-avibactam.<\/jats:p>","DOI":"10.1099\/jmm.0.001211","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T16:14:40Z","timestamp":1593101680000},"page":"928-931","source":"Crossref","is-referenced-by-count":28,"title":["In vitro synergistic activity of the sulbactam\/avibactam combination against extensively drug-resistant Acinetobacter baumannii"],"prefix":"10.1099","volume":"69","author":[{"given":"Carlos Hern\u00e1n","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, INFIBIOC, UBA, Argentina, Avenida C\u00f3rdoba 2351 [1120] Buenos Aires, 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