{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:23:35Z","timestamp":1783459415342,"version":"3.55.0"},"reference-count":21,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"\n Introduction.<\/jats:bold> Even though \n \n Corynebacterium aurimucosum<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> has been described in 2002, this species has long been underestimated due to the unreliability of conventional identification methods and only a few cases of infections have been reported.<\/jats:p>\n \n Hypothesis\/Gap Statement.<\/jats:bold> Little is known about clinical significance and antimicrobial susceptibility profile of this uncommon species.<\/jats:p>\n \n Aim.<\/jats:bold> To evaluate the clinical relevance of \n \n C. aurimucosum<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> and its antimicrobial susceptibility profile.<\/jats:p>\n \n Methodology.<\/jats:bold> All \n \n C. aurimucosum<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolates, collected from 2010 to 2019 in 10 French university hospitals, were retrospectively included. Demographic, clinical and microbiological data were collected for all cases. Antimicrobial susceptibility testing was performed according to the 2019 EUCAST guidelines.<\/jats:p>\n \n Results.<\/jats:bold> Fifty-seven clinical isolates of \n \n C. aurimucosum<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> were collected in 57 patients (median age, 65.8\u2009years; male\/female sex ratio, 1.1), mostly from urine (28\u200a%), blood culture (28\u200a%) and bone\/synovial fluid (19\u200a%) samples. Of them, 14 cases of infection were confirmed, mainly bone and joint infections (50\u200a%) followed by urinary tract infections (UTIs) (21\u200a%), bacteremia (14\u200a%), skin and soft-tissue infections (14\u200a%). \n \n C. aurimucosum<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> was recovered in pure culture in 36\u200a% of cases (UTIs and bacteremia) while mixed cultures were observed for other infections. By testing 52 clinical isolates in vitro<\/jats:italic>, this species appeared to be fully susceptible to linezolid and vancomycin while most isolates (>80\u200a%) were susceptible to amoxicillin (MIC90<\/jats:sub>, 2 \u00b5g ml\u22121<\/jats:sup>), gentamicin, tetracycline and rifampicin. Both cefotaxime and ciprofloxacin seemed to have a limited activity (ca. 50\u200a% of susceptible strains). The MIC distribution for ciprofloxacin showed a bimodal profile with a population of highly-resistant strains with MICs >2 \u00b5g ml\u22121<\/jats:sup>. Most isolates (>90\u200a%) were categorized as resistant to penicillin G and clindamycin.<\/jats:p>\n \n Conclusion.<\/jats:bold> \n \n \n C. aurimucosum<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> should be considered as an actual opportunistic pathogen, and treatment with amoxicillin, vancomycin or linezolid should be preferred.<\/jats:p>","DOI":"10.1099\/jmm.0.001334","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T14:18:11Z","timestamp":1616077091000},"source":"Crossref","is-referenced-by-count":14,"title":["Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum"],"prefix":"10.1099","volume":"70","author":[{"given":"Charles R.","family":"Lef\u00e8vre","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne hospitali\u00e8re, CHU de Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-507X","authenticated-orcid":false,"given":"Romain","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne hospitali\u00e8re, CHU de Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Le Monnier","sequence":"additional","affiliation":[{"name":"Service de Microbiologie Clinique, GH Saint-Joseph, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Corvec","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne hospitali\u00e8re, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bille","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, H\u00f4pital Necker-Enfants malades, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-7947","authenticated-orcid":false,"given":"Ana\u00efs","family":"Potron","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, CHRU de Besan\u00e7on, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-7524","authenticated-orcid":false,"given":"Vincent","family":"Fihman","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne, H\u00f4pital Henri Mondor, AP-HP, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-8018","authenticated-orcid":false,"given":"Eric","family":"Farfour","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, H\u00f4pital Foch, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Amara","sequence":"additional","affiliation":[{"name":"Service de Biologie, Unit\u00e9 de Microbiologie, CH de Versailles, Le Chesnay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Degand","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, CHU de Nice, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-9206","authenticated-orcid":false,"given":"Olivier","family":"Barraud","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie-Virologie-Hygi\u00e8ne, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-9912","authenticated-orcid":false,"given":"Vincent","family":"Cattoir","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne hospitali\u00e8re, CHU de Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the GMC study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.3.227"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.125"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00796-12"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01393-16"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-52-3-1001"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.5.2231-2233.2004"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.5.2197-2202.2004"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06439-11"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0638-0"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01200-18"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1128\/MRA.00391-20"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-91"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.027276-0"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.11.001"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01535-06"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05889-11"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00368-12"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106303"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2010.0032"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.07.001"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01111-17"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001334?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T09:23:59Z","timestamp":1621502639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.001334","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}