{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:50:36Z","timestamp":1787010636631,"version":"build-2736575974"},"reference-count":33,"publisher":"Microbiology Society","issue":"12","funder":[{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["2020A1515010586"],"award-info":[{"award-number":["2020A1515010586"]}]},{"name":"the Science and Technology program of Shenzhen","award":["JCYJ20190809144005609"],"award-info":[{"award-number":["JCYJ20190809144005609"]}]},{"name":"the Shenzhen Key Laboratory of Biochip","award":["ZDSYS201504301534057"],"award-info":[{"award-number":["ZDSYS201504301534057"]}]},{"name":"the Special Support Fund of Shenzhen for Introduced High-Level Medical Team","award":["SZSM201412005"],"award-info":[{"award-number":["SZSM201412005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,24]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Human adenovirus (HAdV) is an important pathogen in acute respiratory tract infections (ARTIs) and HAdV genotypes are associated with disease severity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Hypothesis.<\/jats:bold>\n                    Comparative analyses of clinical features could reveal the severity of different HAdV genotypes in ARTIs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim.<\/jats:bold>\n                    This study aimed to investigate the molecular epidemiology of HAdV infections and explore the correlations between clinical features and HAdV genotypes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methodology.<\/jats:bold>\n                    A retrospective study was conducted on ARTIs at Beijing Chao-Yang Hospital during the period 2011\u20132016. A standardized data form was used to record the clinical information. HAdV was detected by FQ-PCR from respiratory specimens, and genotypes were determined by entire\n                    <jats:italic>hexon<\/jats:italic>\n                    gene sequencing.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    A total of 8044\u2009samples were collected, of which 296 (3.7\u200a%) were HAdV-positive. Patients \u226444\u2009years old were more likely to be positive for HAdV. There were three peak periods of adenoviral infections, with detection rates of 13.03, 9.39 and 10.38\u200a%, respectively. Six HAdV genotypes (HAdV-55, -7, -3, -14, -50, -2) were identified, with HAdV-55 and HAdV-7 being the most prevalent (50.6 and 21.5\u200a%). Compared with HAdV-7 and other types, patients infected with HAdV-55 had a longer duration of fever (\n                    <jats:italic>P<\/jats:italic>\n                    =0.0428). Infections with HAdV-55 and HAdV-7 were more severe compared to those caused by other types, with higher rates of oxygen therapy and mechanical ventilation (\n                    <jats:italic>P<\/jats:italic>\n                    =0.0172\u2009and\n                    <jats:italic>P<\/jats:italic>\n                    =0.0144). All five deaths were caused by HAdV\u201055.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    This study describes the epidemiological characteristics of HAdV infections in North China, revealing the higher severity of HAdV-55 and HAdV-7 in ARTIs. Thus, strengthened surveillance of HAdV genotypes is warranted.\n                  <\/jats:p>","DOI":"10.1099\/jmm.0.001445","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T08:17:32Z","timestamp":1640333852000},"source":"Crossref","is-referenced-by-count":14,"title":["Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections"],"prefix":"10.1099","volume":"70","author":[{"given":"Qing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Shenzhen Third People\u2019s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-8703","authenticated-orcid":false,"given":"Shuyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Third 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