{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:49:00Z","timestamp":1772516940984,"version":"3.50.1"},"reference-count":41,"publisher":"Microbiology Society","issue":"1","funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN203618"],"award-info":[{"award-number":["IN203618"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN203621"],"award-info":[{"award-number":["IN203621"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,10]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> \n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.11017\" xlink:type=\"simple\">Salmonella enterica<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> serovar Typhi (<jats:italic>S<\/jats:italic>. Typhi) is the etiological agent of typhoid fever. To establish an infection in the human host, this pathogen must survive the presence of bile salts in the gut and gallbladder.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Hypothesis.<\/jats:bold> \n                  <jats:italic>S<\/jats:italic>. Typhi uses multiple genetic elements to resist the presence of human bile.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aims.<\/jats:bold> To determine the genetic elements that <jats:italic>S<\/jats:italic>. Typhi utilizes to tolerate the human bile salt sodium deoxycholate.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> A collection of <jats:italic>S<\/jats:italic>. Typhi mutant strains was evaluated for their ability to growth in the presence of sodium deoxycholate and ox-bile. Additionally, transcriptomic and proteomic responses elicited by sodium deoxycholate on <jats:italic>S<\/jats:italic>. Typhi cultures were also analysed.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> Multiple transcriptional factors and some of their dependent genes involved in central metabolism, as well as in cell envelope, are required for deoxycholate resistance.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> These findings suggest that metabolic adaptation to bile is focused on enhancing energy production to sustain synthesis of cell envelope components exposed to damage by bile salts.<\/jats:p>","DOI":"10.1099\/jmm.0.001461","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T16:17:10Z","timestamp":1641831430000},"source":"Crossref","is-referenced-by-count":9,"title":["The human bile salt sodium deoxycholate induces metabolic and cell envelope changes in Salmonella Typhi leading to bile 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