{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:40:30Z","timestamp":1770568830720,"version":"3.49.0"},"reference-count":45,"publisher":"Microbiology Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,10]]},"abstract":"\n Introduction.<\/jats:bold> Invasive meningococcal disease is a major health problem, impacting morbidity and mortality worldwide. Exploratory genomics has revealed insights into adaptation, transmissibility and virulence to elucidate endemic, outbreaks or epidemics caused by \n \n Neisseria meningitidis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> serogroup W (MenW) strains.<\/jats:p>\n \n Gap Statement.<\/jats:bold> Limited information on the genomics of Neisseria meningitis<\/jats:italic> serogroup W ST11\/cc11 is available from emerging countries, especially in contemporary isolates.<\/jats:p>\n \n Aim.<\/jats:bold> To (i) describe the antigenic diversity and distribution of genetic lineages of \n \n N. meningitidis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> serogroup W circulating in Brazil; (ii) study the carriage prevalence of hypervirulent clones in adolescents students and (iii) analyse the potential risk factors for meningococcal carriage.<\/jats:p>\n \n Methodology.<\/jats:bold> Using whole-genome sequencing, we analysed the genomic diversity of 92 invasive \n \n N. meningitidis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> serogroup W isolates circulating in Brazil from 2016 to 2019. A cross-sectional survey of meningococcal carriage was conducted in 2019, in the city of Florian\u00f3polis, Brazil, among a representative sample of 538 students.<\/jats:p>\n \n Results.<\/jats:bold> A predominance (58.5\u200a%, 41\/82) of ST11\/cc11 presenting PorB2-144, PorA VR1\u20135, VR2-2, FetA 1\u20131, and a novel fHbp peptide 1241 was found on invasive \n \n N. meningitidis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> W isolates, on the other hand, a high diversity of clonal complexes was found among carriage isolates. The overall carriage rate was 7.5\u200a% (40\/538). A total of 28 of 538 swab samples collected were culture positive for \n \n N. meningitidis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>, including four serogroup\/genogroup B isolates (14.8\u200a%;4\/27), 1 serogroup\/genogroup Y isolate (3.7\u200a%;1\/27), 22 (81.5\u200a%; 22\/27) non-groupable isolates. No MenW isolate was identified among carriages isolates.<\/jats:p>\n \n Conclusion.<\/jats:bold> This report describes the emergence of the new MenW ST11\/cc11 South America sublineage variant, named here, 2016 strain, carrying a novel fHbp peptide 1241, but its emergence, was not associated with an increased MenW carriage prevalence. Continuous surveillance is necessary to ascertain the role of this sublineage diversification and how its emergence can impact transmission.<\/jats:p>","DOI":"10.1099\/jmm.0.001484","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T10:15:42Z","timestamp":1644574542000},"source":"Crossref","is-referenced-by-count":5,"title":["Emergence of Neisseria meningitidis W South American sublineage strain variant in Brazil: disease and carriage"],"prefix":"10.1099","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7205-576X","authenticated-orcid":false,"given":"Ana Paula Silva de","family":"Lemos","sequence":"first","affiliation":[{"name":"Centro de Bacteriologia, Instituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-7479","authenticated-orcid":false,"given":"Maria Cecilia Outeiro","family":"Gorla","sequence":"additional","affiliation":[{"name":"Centro 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