{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:40:36Z","timestamp":1784288436332,"version":"3.55.0"},"reference-count":42,"publisher":"Microbiology Society","issue":"3","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["19KO7550"],"award-info":[{"award-number":["19KO7550"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"crossref","award":["JPMH19HA100"],"award-info":[{"award-number":["JPMH19HA100"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,3]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Only approximately 40 cases of invasive meningococcal diseases are reported annually in Japan, and the dominant strains are serogroup Y meningococci (MenY) followed by serogroup B meningococci (MenB). Within the last 10 years, <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1926\" xlink:type=\"simple\">Neisseria meningitidis<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> strains belonging to clonal complex (cc)2057 have become dominant among Japanese MenB and have not been identified in countries other than Japan.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Hypothesis\/Gap Statement.<\/jats:bold> The uniqueness of cc2057 <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1926\" xlink:type=\"simple\">N. meningitidis<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> strains was considered to be epidemiologically of importance, and some genetic features could be hidden in the genome of cc2057 meningococci.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Method.<\/jats:bold> We investigated 22 cc2057 MenB and one cc2057 MenY using whole genome sequencing (WGS) and also predicted the potential coverage of 4CMenB and bivalent rLP2086 vaccines <jats:italic>in silico<\/jats:italic>.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> cc2057 <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1926\" xlink:type=\"simple\">N. meningitidis<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> strains were phylogenetically assigned to two clades. Three hypothetical genes homologous to those in <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1924\" xlink:type=\"simple\">Neisseria lactamica<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> and sequences related to a new CRISPR Cas9 system were found only in the genome of cc2057 strains. Moreover, one cc2057 MenY strain was presumed to be capsular-switched at the capsule synthesis (<jats:italic>cps<\/jats:italic>) locus. The potential coverage of 4CMenB and rLP2086 for cc2057 MenB strains was estimated to be very low.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> To the best of our knowledge, this is the first study to provide genetic insights from epidemiologically unique <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1926\" xlink:type=\"simple\">N. meningitidis<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> cc2057 strains isolated only in Japan, an island country.<\/jats:p>","DOI":"10.1099\/jmm.0.001504","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T15:15:55Z","timestamp":1646320555000},"source":"Crossref","is-referenced-by-count":7,"title":["Genetic characterization of clonal complex sequence type 2057 (cc2057) serogroup B Neisseria meningitidis strains unique to Japan and identification of a capsular-switched serogroup Y isolate cc2057"],"prefix":"10.1099","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-8043","authenticated-orcid":false,"given":"Hideyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-0053","authenticated-orcid":false,"given":"Masatomo","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, 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