{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:59:23Z","timestamp":1792205963501,"version":"4.4.0"},"reference-count":35,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2017\/16988-6, 2017\/50333-7, 2018\/21192-9, 2018\/21193-5, 2020\/06157-2"],"award-info":[{"award-number":["2017\/16988-6, 2017\/50333-7, 2018\/21192-9, 2018\/21193-5, 2020\/06157-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["Productivity Research Fellows"],"award-info":[{"award-number":["Productivity Research Fellows"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,27]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction<\/jats:bold>. Carbapenem-resistant <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2767\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> (CRAB) is the primary pathogen causing hospital-acquired infections. The spread of CRAB is mainly driven by the dissemination of resistant clones, and in Latin America, International Clones IC-1 (also known as clonal complex CC1), IC-4 (CC15) and IC-5 (CC79) are the most prevalent.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Gap Statement.<\/jats:bold> There are no documented outbreaks of CRAB International Clone 2 (IC-2) reported in Brazil.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim.<\/jats:bold> To describe a large outbreak of CRAB caused by the uncommon IC-2 in a Brazilian COVID-19 hospital.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> From May 2020 to May 2021, 224\u2009patients infected or colonized with CRAB were identified in a single hospital; 92\u200a% of them were also infected with SARS-CoV-2. From these patients, 137 isolates were recovered and subjected to antimicrobial susceptibility testing, PCR analysis and molecular typing. Whole-genome sequencing and downstream analysis were carried out on a representative isolate (the first available isolate).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> In 76\u200a% of the patients, a single OXA-23-producing CRAB IC-2 was identified. All the isolates were susceptible to polymyxin B, but highly resistant (&gt;95\u200a%) to aminoglycosides, fluoroquinolones and beta-lactams. Genomic analysis revealed that the representative isolate also carried the 16S rRNA Methylase ArmA, which was detected for the first time in this species in Brazil.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> We report the rapid spread of an emerging CRAB clone responsible for causing a large outbreak in a hospital in Brazil, a country with predominance of other CRAB clones. Continuous and prospective surveillance is warranted to evaluate the impact of this clone in Brazilian hospital settings.<\/jats:p>","DOI":"10.1099\/jmm.0.001509","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T16:17:17Z","timestamp":1649866637000},"source":"Crossref","is-referenced-by-count":27,"title":["Clonal spread of ArmA- and OXA-23-coproducing Acinetobacter baumannii International Clone 2 in Brazil during the first wave of the COVID-19 pandemic"],"prefix":"10.1099","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-0085","authenticated-orcid":false,"given":"Carlos Henrique","family":"Camargo","sequence":"first","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Yaeko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Onishi","family":"Nagamori","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia Rodrigues","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique Ribeiro","family":"Tiba-Casas","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Aparecida","family":"de Moraes Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Grupo de Vigil\u00e2ncia Epidemiol\u00f3gica VIII, Mogi das Cruzes, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Helena Trigueiro N\u00f3brega","family":"Porto","sequence":"additional","affiliation":[{"name":"Grupo de Vigil\u00e2ncia Epidemiol\u00f3gica VIII, Mogi das Cruzes, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda Lourdes","family":"de Lima Garzon","sequence":"additional","affiliation":[{"name":"Grupo de Vigil\u00e2ncia Epidemiol\u00f3gica VIII, Mogi das Cruzes, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Higgins","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner site Bonn-Cologne, Cologne, Germany"},{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-6205","authenticated-orcid":false,"given":"Geraldine","family":"Madalosso","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Infec\u00e7\u00e3o Hospitalar, Centro de Vigil\u00e2ncia Epidemiol\u00f3gica, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Brand\u00e3o","family":"de Assis","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Infec\u00e7\u00e3o Hospitalar, Centro de Vigil\u00e2ncia Epidemiol\u00f3gica, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.03.024"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0127-9"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02186-15"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.09.008"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.09.028"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0262"},{"key":"R8","article-title":"BR Cast. 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