{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:21:08Z","timestamp":1773901268309,"version":"3.50.1"},"reference-count":46,"publisher":"Microbiology Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> \n                  <jats:italic>Candida<\/jats:italic> spp. may cause opportunistic infections called vulvovaginal candidiasis (VVC), which is estimated to be the second most common cause of vaginitis worldwide.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Gap Statement.<\/jats:bold> Under various circumstances, VVC could compromise pregnancy outcomes. Emerging data suggests that VVC during pregnancy may be associated with increased risk of complications and congenital cutaneous candidiasis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim.<\/jats:bold> To assess the prevalence of <jats:italic>Candida<\/jats:italic> spp. in asymptomatic pregnant women and determine the susceptibility of the isolates to antifungal drugs.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> In a prospective cohort, 65 high vaginal swab samples of consented pregnant women. <jats:italic>Candida<\/jats:italic> isolates were identified using both microbiological and molecular tools and drug susceptibilities were profiled.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> The prevalence of VVC among our study participants was 37\u200a%, 24 of the 65 asymptomatic pregnant women show <jats:italic>Candida<\/jats:italic> spp. colonization. <jats:italic>C. albicans<\/jats:italic> was the most common species 61\u200a%, followed by <jats:italic>C. glabrata<\/jats:italic> 39 %. In addition, a significant fraction of the isolated colonies showed resistance to Fluconazole, with a ratio of 63\u2009% for <jats:italic>C. albicans<\/jats:italic> isolates and 16\u200a% for <jats:italic>Candida glabrata<\/jats:italic> isolates. Moreover, relative quantification of genes related to resistance to fluconazole, CDR1, ERG11 as well as HWP1, showed a significant change compared to controls.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Monitoring of vaginal <jats:italic>Candida c<\/jats:italic>olonization before the third trimester of pregnancy, that could reduce congenital <jats:italic>Candida<\/jats:italic> colonization and risk of pregnancy complications.<\/jats:p>","DOI":"10.1099\/jmm.0.001589","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T18:17:35Z","timestamp":1663697855000},"source":"Crossref","is-referenced-by-count":3,"title":["Microbiological and molecular screening of Candida spp. isolated from genital tract of asymptomatic pregnant women"],"prefix":"10.1099","volume":"71","author":[{"given":"Wafa","family":"Bouglita","sequence":"first","affiliation":[{"name":"Higher Institute of Biotechnology of Sidi Thabet, University 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