{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:36:45Z","timestamp":1788961005728,"version":"build-2803163510"},"reference-count":30,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,19]]},"abstract":"\n Introduction.<\/jats:bold> Bone and joint tuberculosis (BJTB) is rare in developed countries, particularly in the paediatric population.<\/jats:p>\n \n Hypothesis\/Gap Statement.<\/jats:bold> The clinical features and sequelae of paediatric BJTB in Europe are not well characterized and should be assessed to achieve a better approach.<\/jats:p>\n \n Aim.<\/jats:bold> To assess the management and outcomes of paediatric BJTB.<\/jats:p>\n \n Methodology.<\/jats:bold> Longitudinal observational study of all paediatric patients (0\u201317\u2009years old) diagnosed with BJTB between 2008 to 2020 in a tertiary-care hospital.<\/jats:p>\n \n Results.<\/jats:bold> We identified 18\u2009patients with BJTB, with a median age of 10\u2009years (IQR 6\u201314.8), 66.7\u200a%\u2009male. Most (72\u200a%) were diagnosed after 2015 and were foreign-born (88.9\u200a%), mainly from Portuguese-speaking African countries, and none had HIV. The most common symptoms were pain (77.8\u200a%), fever (50\u200a%) and bone deformity (44.4\u200a%). Spinal TB (STB) affected 13 (72.2\u200a%) and extra-spinal TB (ESTB) 9 (50\u200a%) patients, and 4 (27.7\u200a%) had both conditions. Diagnostic positive procedures included positive nucleic acid amplification technique (NAAT) (44.4\u200a%), \n \n Mycobacterium tuberculosis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolation (44.4\u200a%) and compatible histology (33.3\u200a%). All completed antituberculous drugs for a median of 12\u2009months (IQR 12\u201313) and nine (50\u200a%) had surgery. Overall, acute complications occurred in 16 (88.9\u200a%) patients \u2013 11\/13 (84.6\u200a%) with STB and 5\/5 (100\u200a%) with ESTB \u2013 and included abscesses, spinal compression, spine deformity and pathological fractures. Sequelae were still present at the 12-month follow-up in seven\u2009cases (46.7\u200a%), and were more common in foreign-born patients sent to Portugal to receive medical treatment (66.7 vs 20\u200a%).<\/jats:p>\n \n Conclusions.<\/jats:bold> Paediatric BJTB is difficult to diagnose and has high morbidity, requiring long-term follow-up. Over the last decade, foreign-born TB seems to be increasing, with still longer treatment courses and more acute complications and sequelae.<\/jats:p>","DOI":"10.1099\/jmm.0.001610","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T18:17:10Z","timestamp":1671473830000},"source":"Crossref","is-referenced-by-count":4,"title":["Bone and joint tuberculosis in paediatrics: a 13-year retrospective study"],"prefix":"10.1099","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-8473","authenticated-orcid":false,"given":"Catarina","family":"Gouveia","sequence":"first","affiliation":[{"name":"Nova Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal"},{"name":"Paediatric Infectious Diseases Unit, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e0rio Lisboa Central (CHULC) \u2013 EPE, Lisbon, 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