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The present study evaluated the <jats:italic>in vitro<\/jats:italic> antibiofilm activity of sertraline in reducing the cell viability of forming and matured biofilms, in addition to elucidating whether effective concentrations are safe. Sertraline reduced biofilm cell viability by more than 80\u200a% for all <jats:italic>Candida<\/jats:italic> species tested, acting at low and safe concentrations, both on mature biofilm and in preventing its formation, even the one with highest virulence. Its preventive mechanism seemed to be related to binding with ALS3. These data indicate that sertraline is a promising drug with anticandidal biofilm potential in safe doses. However, further studies are needed to elucidate the antibiofilm mechanism and possible application of pharmaceutical forms.<\/jats:p>","DOI":"10.1099\/jmm.0.001664","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T09:18:50Z","timestamp":1676020730000},"source":"Crossref","is-referenced-by-count":13,"title":["Sertraline has in vitro activity against both mature and forming biofilms of different Candida species"],"prefix":"10.1099","volume":"72","author":[{"given":"Daniel Sampaio","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Center of Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza, CE, Brazil"},{"name":"School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Cear\u00e1, Fortaleza, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria Pessoa de 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