{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:23:09Z","timestamp":1784082189026,"version":"3.55.0"},"reference-count":26,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,12]]},"abstract":"<jats:p>\n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1910\" xlink:type=\"simple\">Neisseria gonorrhoeae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is a bacterial pathogen that causes gonorrhoea, a sexually transmitted infection. Increasing antimicrobial resistance in <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1910\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is providing motivation to develop new treatment options. In this study, we investigated the effectiveness of the antibiotic ramoplanin as a treatment for <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1910\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> infection. We tested the effectiveness of ramoplanin <jats:italic>in vitro<\/jats:italic> against 14 World Health Organization (WHO) reference strains of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1910\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> and found that it was active against all 14 strains tested. Furthermore, in a <jats:italic>Galleria mellonella<\/jats:italic> infection model of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1910\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> WHO P, we demonstrated that ramoplanin was active <jats:italic>in vivo<\/jats:italic> without any evidence of toxicity. This suggests that ramoplanin might be a new promising antibiotic treatment for gonorrhoea.<\/jats:p>","DOI":"10.1099\/jmm.0.001785","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:16:52Z","timestamp":1705065412000},"source":"Crossref","is-referenced-by-count":5,"title":["Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella"],"prefix":"10.1099","volume":"73","author":[{"given":"Zina","family":"Gestels","sequence":"first","affiliation":[{"name":"STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp 2000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irith","family":"De Baetselier","sequence":"additional","affiliation":[{"name":"Clinical and Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Abdellati","sequence":"additional","affiliation":[{"name":"Clinical and Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeba Santhini","family":"Manoharan-Basil","sequence":"additional","affiliation":[{"name":"STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp 2000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-8998","authenticated-orcid":false,"given":"Chris","family":"Kenyon","sequence":"additional","affiliation":[{"name":"STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp 2000, Belgium"},{"name":"Division of Infectious Diseases and HIV Medicine, University of Cape Town, Cape Town 7700, South 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