{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:22Z","timestamp":1790009542693,"version":"4.0.1"},"reference-count":29,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,6]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Colistin (polymyxin E) has emerged as a last-resort treatment option for multidrug-resistant infections.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Hypothesis\/Gap Statement.<\/jats:bold> Studies on the use, safety and efficacy of colistin in South Africa are limited.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim<\/jats:bold>. This study aims to describe the use of colistin and its clinical outcomes at a tertiary public hospital in South Africa.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> We conducted a retrospective review of adult and paediatric patients who received parenteral colistin between 2015 and 2019.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> A total of 69\u2009patients (26 adults, 13 children and 30 neonates) were reviewed. <jats:italic>Acinetobacter baumannii<\/jats:italic> was the most common causative pathogen isolated (70.1\u200a%). Colistin was predominately used to treat septicaemia (75.4\u200a%). It was primarily administered as definitive therapy (71.0\u200a%) and as monotherapy (56.5\u200a%). It was used in 11.5\u200a% of adults with infections susceptible to other antibiotics. Loading doses of intravenous colistin were administered in only 15 (57.7\u200a%) adult patients. Neurotoxicity and nephrotoxicity occurred in 5.8\u200a% and 43.5\u200a% of patients, respectively. Clinical cure was achieved in 37 (53.6\u200a%) patients. On multivariate logistic regression analysis, adults [adjusted odds ratio (aOR), 25.54; 95\u200a% CI, 2.73\u2013238.65; <jats:italic>P<\/jats:italic> &lt; 0.01] and children (aOR, 8.56; 95\u200a%\u2009CI, 1.06\u201369.10; <jats:italic>P<\/jats:italic> &lt; 0.05) had higher odds of death than neonates.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> The study identified significant stewardship opportunities to improve colistin prescription and administration. Achieving optimal patient outcomes necessitates a multidisciplinary approach and vigilant monitoring of colistin use.<\/jats:p>","DOI":"10.1099\/jmm.0.001840","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T14:16:11Z","timestamp":1717683371000},"source":"Crossref","is-referenced-by-count":3,"title":["Colistin utilization at a tertiary hospital in South Africa: an opportunity for antimicrobial stewardship practices"],"prefix":"10.1099","volume":"73","author":[{"given":"Gaalebale Prudence","family":"Matshediso","sequence":"first","affiliation":[{"name":"Department of Public Health, Faculty of Health Sciences, University of Fort Hare, East London, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3130-9724","authenticated-orcid":false,"given":"Oyewole Christopher","family":"Durojaiye","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK"},{"name":"Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-6701","authenticated-orcid":false,"given":"Oladele Vincent","family":"Adeniyi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Cecilia Makiwane Hospital, Faculty of Medicine & Health Sciences, Walter Sisulu University, East London 5200, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","volume-title":"Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2022","year":"2022"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S234610"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2021.09.021"},{"key":"R4","first-page":"457","article-title":"A new antibiotic \u2018Colistin\u2019 produced by 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