{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:18:22Z","timestamp":1774865902999,"version":"3.50.1"},"reference-count":16,"publisher":"Microbiology Society","issue":"6","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,26]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Fluoroquinolone prophylaxis during haematopoietic cell transplantation (HCT) can lead to antimicrobial resistance (AMR). Identifying the groups of patients that have the highest likelihood of benefiting from prophylactic antimicrobials is important for antimicrobial stewardship (AMS).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Hypothesis.<\/jats:bold> We aimed to identify groups of HCT recipients that have the highest likelihood of benefiting from prophylactic fluroquinolones.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods.<\/jats:bold> All admissions for HCT in a tertiary centre between January 2020 and December 2022 (<jats:italic>N<\/jats:italic> = 400) were retrospectively studied. Allogeneic HCT (allo-HCT) recipients had prophylaxis with ciprofloxacin during the chemotherapy-induced neutropenia, while autologous HCT (auto-HCT) recipients did not. Bacteraemias were recorded when non-contaminant bacterial pathogens were isolated in blood cultures.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> Allo-HCT was performed for 43.3\u200a% (173\/400) of patients and auto-HCT was performed for 56.7\u200a% (227\/400). A bacteraemia was documented in 28.3\u200a% (113\/400) of cases. Allo-HCT recipients were more likely to have a Gram-positive bacteraemia (20.8%, 36\/173, vs 10.1%, 23\/227, <jats:italic>P<\/jats:italic> = 0.03), while a difference was not observed for Gram-negative bacteraemias (18.5%, 32\/173 vs 18.1%, 41\/227, <jats:italic>P<\/jats:italic> = 0.91). Among auto-HCT recipients not receiving ciprofloxacin prophylaxis, patients with germ cell tumours had the highest probability (<jats:italic>P<\/jats:italic> for trend 0.09) of recording any bacteraemia (43.5%, 10\/23) followed by patients with lymphomas (32.5%, 13\/40), other auto-HCT indications (22.2%, 2\/9), multiple myeloma (22.1%, 29\/131) and multiple sclerosis (12.5%, 3\/24). The higher number of bacteraemias in patients with germ cell tumours was primarily driven by Gram-negative pathogens.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions.<\/jats:bold> Ciprofloxacin prophylaxis was associated with a reduced incidence of Gram-negative bacteraemias in allo-HCT recipients. Auto-HCT recipients due to germ cell tumours, not receiving ciprofloxacin prophylaxis, recorded the highest incidence of bacteraemias and represent a possible target group for this intervention.<\/jats:p>","DOI":"10.1099\/jmm.0.001847","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T15:17:42Z","timestamp":1719415062000},"source":"Crossref","is-referenced-by-count":1,"title":["Ciprofloxacin prophylaxis during haematopoietic cell transplantation: a role for use in patients with germ cell tumours?"],"prefix":"10.1099","volume":"73","author":[{"given":"Konstantinos","family":"Kavallieros","sequence":"first","affiliation":[{"name":"Department of Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK"},{"name":"Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-4835","authenticated-orcid":false,"given":"Ioannis","family":"Baltas","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Department of Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannis","family":"Konstantinou","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Koutoumanou","sequence":"additional","affiliation":[{"name":"Population, Policy & Practice Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malick M.","family":"Gibani","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College NHS Healthcare Trust, St Mary's Hospital, London, UK"},{"name":"Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Pavlu","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","volume-title":"Open Forum Infectious Diseases","author":"Schuster"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004386.pub3"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1159\/000535119"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1136\/dtb.2019.000050"},{"key":"R5","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","volume":"3425","author":"Young","year":"2015"},{"key":"R6","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-02278-5","volume-title":"The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular 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Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001847?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T15:17:46Z","timestamp":1719415066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,26]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.001847","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}