{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:12:35Z","timestamp":1788588755120,"version":"build-2803163510"},"reference-count":21,"publisher":"Microbiology Society","issue":"10","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007398","name":"Secretaria de Estado de Sa\u00fade de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007398","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,9]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Efforts to understand the burden of antibiotic use in low- and middle-income countries such as Brazil are essential for developing strategies that are effective and appropriate in the context of endemic multidrug-resistant organisms.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim.<\/jats:bold> This study aims to determine antimicrobial-prescribing practices among patients hospitalized in intensive care units (ICUs) for adults in Brazil.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> A 1-day point prevalence multicentre survey was conducted in 58 adult ICUs across the five regions of Brazil. The institutions were categorized according to their type and size. Detailed antimicrobial prescription data were prospectively provided to all patients hospitalized on the day of data collection.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> A total of 620\u2009patients were included in the study, of whom 63.9% were receiving at least one antimicrobial. Of these, 34.6% were treated for an infection, but only 39.9% of the cases were based on microbiological criteria. Empirical treatment was applied to 72.3% of the patients. Significant differences in antibiotic usage were observed across the different hospitals included in the study. Overall, treatment was most commonly directed towards pneumonia (51.8%) and bloodstream infections (29.6%). Glycopeptides (19.4%) and carbapenems (18.5%) were the most prescribed in teaching hospitals, while in non-teaching hospitals, carbapenems (17.8%) and broad-spectrum cephalosporins (16.8%) were most frequently used.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Our study reveals alarming data on antibiotic use in adult ICUs in Brazil, with high frequencies of severe healthcare-associated infections acquired in these units, where patients are frequently subjected to empirical treatment.<\/jats:p>","DOI":"10.1099\/jmm.0.001908","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T16:18:02Z","timestamp":1728490682000},"source":"Crossref","is-referenced-by-count":5,"title":["Towards an update on the antimicrobial use in Adult Care Units in Brazil: insights from multi-hospital prevalence study"],"prefix":"10.1099","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-7360","authenticated-orcid":false,"given":"Luiz Gustavo","family":"Machado","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-6110","authenticated-orcid":false,"given":"Daiane Silva","family":"Resende","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9384-7582","authenticated-orcid":false,"given":"Paola Amaral","family":"de Campos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-085X","authenticated-orcid":false,"given":"Melina Lorraine","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-7099","authenticated-orcid":false,"given":"Iara","family":"Rossi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-8576","authenticated-orcid":false,"given":"Iolanda Alves","family":"Braga","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-374X","authenticated-orcid":false,"given":"Caio Augusto Martins","family":"Aires","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5984-7168","authenticated-orcid":false,"given":"Maria Tereza","family":"Freitas Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Hospital Infection Control Service, Casa de Miseric\u00f3rdia de Macei\u00f3, Macei\u00f3, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-6585","authenticated-orcid":false,"given":"L\u00edcia Ludendorff","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7142-4375","authenticated-orcid":false,"given":"Vitelhe Ferreira","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-1100","authenticated-orcid":false,"given":"Paulo Pinto","family":"Gontijo-Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-6832","authenticated-orcid":false,"given":"Rosineide Marques","family":"Ribas","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00016-10"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773215Y.0000000030"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61458-4"},{"key":"R4","article-title":"Diretriz Nacional para Elabora\u00e7\u00e3o de Programa de Gerenciamento do Uso de Antimicrobianos em Servi\u00e7os de Sa\u00fade","year":"2017"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2019.1581371"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1590\/s1413-86702007000300011"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-81232013001000030"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.5123\/S2176-6223201900041"},{"key":"R9","article-title":"Report on the burden of endemic health care-associated infection worldwide","year":"2011"},{"key":"R10","article-title":"Crit\u00e9rios Diagn\u00f3sticos de Infec\u00e7\u00e3o Relacionada \u00e0 Assist\u00eancia \u00e0 Sa\u00fade","year":"2013"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02166-13"},{"key":"R13","article-title":"Antibiotic resistance threats in the United States","year":"2019"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30186-4"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv418"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1813023"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2017.6839"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153696"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2018.03.003"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm357"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001908?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T16:18:04Z","timestamp":1728490684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,9]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.001908","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]}}}