{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T01:37:49Z","timestamp":1787189869077,"version":"build-2736575974"},"reference-count":52,"publisher":"Microbiology Society","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Carbapenems are usually employed as first-line antimicrobials against bacteria harbouring extended-spectrum beta-lactamases (ESBLs). These enzymes confer resistance often to multiple classes of antimicrobials.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Hypothesis\/Gap Statement.<\/jats:bold>\n                    This indiscriminate use of carbapenems and the inevitable development of carbapenem resistance have prompted the need for carbapenem-sparing strategies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methodology.<\/jats:bold>\n                    The non-carbapenem antimicrobial susceptibility patterns of 60 ESBL-producing\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    (ESBL-PE) isolates responsible for bloodstream infections, in 2022\u20132023 inclusive, processed at our institution were reviewed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    The non-carbapenem antimicrobial susceptibility patterns of 60 ESBL-PE isolates from bloodstream infections during the study period were determined.\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    was the most common species isolated (87%,\n                    <jats:italic>n<\/jats:italic>\n                    =52), with the majority of cases (73.3%,\n                    <jats:italic>n<\/jats:italic>\n                    =44) originating from a presumed urinary source. Temocillin (TMC), mecillinam (MEC), cefiderocol (FDC), amikacin and fosfomycin (FOS) displayed excellent activity against all ESBL-PE isolates tested, with susceptibility rates of\u226585%. Ciprofloxacin and amoxicillin\u2013clavulanic acid were the least efficacious agents, with susceptibility rates\u226420%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    TMC, MEC, FDC and FOS offer promising alternatives to carbapenems, demonstrating efficacy against ESBL-PE. The use of these agents not only broadens the therapeutic arsenal against ESBL-PE but also mitigates the potential for escalating carbapenem resistance, especially in regions where the incidence of carbapenem resistance is increasing.\n                  <\/jats:p>","DOI":"10.1099\/jmm.0.001955","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:19:21Z","timestamp":1738739961000},"source":"Crossref","is-referenced-by-count":5,"title":["Preserving the antimicrobial arsenal: exploring alternatives to carbapenems in ESBL battles within the southeast of Ireland"],"prefix":"10.1099","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1207-4352","authenticated-orcid":false,"given":"Saied","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"},{"name":"Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aideen","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lapthorne","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meadhbh","family":"Collison","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doireann","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11112937"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlab092"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/848194"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.02.011"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020061"},{"key":"R6","article-title":"Antimicrobial resistance surveillance in Europe 2023 - 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