{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:29:08Z","timestamp":1792250948331,"version":"4.4.0"},"reference-count":77,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that presents significant challenges in terms of treatment owing to a pronounced likelihood of recurrence and an elevated risk of cancer development, thereby imposing substantial risks on affected individuals. The gut microbiota of Firmicutes and Bacteroidetes (F\/B) can affect diseases associated with IBD, which is also a risk factor for breast cancer. This review discusses the hazards associated with UC, highlights the existing disparities in UC-associated gut microbiome research, explores the concept of the F\/B ratio and scrutinizes its correlation with UC. Moreover, the differences in the F\/B ratios between healthy individuals and those with UC were thoroughly examined. These findings suggest that an elevated F\/B ratio may promote the occurrence and progression of UC. Consequently, the F\/B ratio may play a significant role in UC by influencing gut microbiota composition and inflammatory responses, suggesting that future research should focus on this ratio as a potential biomarker for disease progression and therapeutic targets in managing UC.<\/jats:p>","DOI":"10.1099\/jmm.0.001966","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T07:19:47Z","timestamp":1738307987000},"source":"Crossref","is-referenced-by-count":50,"title":["Progress in the investigation of the Firmicutes\/Bacteroidetes ratio as a potential pathogenic factor in ulcerative colitis"],"prefix":"10.1099","volume":"74","author":[{"given":"Yu","family":"Yin","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiezheng","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Tian","sequence":"additional","affiliation":[{"name":"Hainan Provincial People's Hospital, Haikou 570100, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Shi","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqiu","family":"Yan","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Bao\u2019an Authentic TCM Therapy Hospital, Shenzhen 518000, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02144"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.028"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00796-x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161141"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.07.012"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.577236"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12795"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3444"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01389-7"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.027"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104978"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303333"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-019-0263-2"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302311"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.063"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.010"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i29.3833"},{"key":"R18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ajhg.2021.02.001","article-title":"Whole-genome sequencing of african americans implicates differential genetic architecture in inflammatory bowel disease","volume":"108","author":"SH","year":"2021","journal-title":"Am J Hum Genet"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58050567"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15389"},{"key":"R21","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.mayocp.2014.07.002","article-title":"Ulcerative colitis: epidemiology, diagnosis, and management","volume":"89","author":"Feuerstein","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706625104"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8787"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2236-y"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2013.825700"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13050409"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091900"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00072"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081887"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.11.017"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1038\/srep00574"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01452-1"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05901-2"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.849985"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12849"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(02)74129-5"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-017-9311-9"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-4946-2"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.3920\/BM2016.0110"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2017.06.010"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111715"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00101"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(03)73619-4"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.598010"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2478"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.2741\/3603"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504978102"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134333"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-1027-1"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.15-152"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084689"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.09.039"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.155"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i8.1146"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i12.1969"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00171.2015"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0011-z"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062216"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02269-6"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aap8914"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.18699\/VJ21.100"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.073817"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.882924"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.04.009"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01004-06"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.162091"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20151"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1080\/003655201753265082"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02503-5"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111715"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.05.026"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.030"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.733992"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2942"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328339536b"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001966?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T07:19:50Z","timestamp":1738307990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,31]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.001966","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}