{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:49:43Z","timestamp":1787701783705,"version":"build-2784847793"},"reference-count":51,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001704","name":"European Society of Clinical Microbiology and Infectious Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001704","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:title>Graphical abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Mycoplasma genitalium<\/jats:italic> infections are enabled by multiple virulence factors, both intracellular and expressed on the cholesterol-containing phospholipid membrane. Intracellular accessory proteins form the tip structure, which adheres to epithelial cells <jats:italic>in vivo<\/jats:italic> via the transmembrane adhesion complex of Nap proteins, P110 and P140. Protein M binds to the Fab region of immunoglobulins with a high affinity to both \u03bb and \u03ba chains, enabling immune system evasion. Membrane lipoproteins and extracellular polymeric substances help in biofilm formation, which is thought to facilitate infection persistence.<\/jats:p>\n               <jats:p>\n                  <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"jmm001984-f1.png\"\/>\n               <\/jats:p>","DOI":"10.1099\/jmm.0.001984","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T15:18:37Z","timestamp":1743779917000},"source":"Crossref","is-referenced-by-count":4,"title":["JMM Profile: Mycoplasma genitalium: a small, yet significant pathogen"],"prefix":"10.1099","volume":"74","author":[{"given":"Tia","family":"Rudman","sequence":"first","affiliation":[{"name":"School of Biosciences, Cardiff University, Cardiff, UK"},{"name":"Microbiology and Infection Research Group, Department of Biomedical Sciences, Cardiff Metropolitan University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Rowlands","sequence":"additional","affiliation":[{"name":"Microbiology and Infection Research Group, Department of Biomedical Sciences, Cardiff Metropolitan University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-7435","authenticated-orcid":false,"given":"Jorgen S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-0772","authenticated-orcid":false,"given":"Michael L.","family":"Beeton","sequence":"additional","affiliation":[{"name":"Microbiology and Infection Research Group, Department of Biomedical Sciences, Cardiff Metropolitan University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the ESCMID Study Group for Mycoplasma and Chlamydia Infections (ESGMAC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","first-page":"524","article-title":"Urogenital mycoplasma infections of man: a review with observations on a recently discovered mycoplasma","volume":"17","author":"Taylor-Robinson","year":"1981","journal-title":"Isr J Med Sci"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92461-2"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.1.46-50.1991"},{"key":"R4","first-page":"107","article-title":"Mycoplasma genitalium prevalence, symptoms, signs and treatment efficacy among attendees at a swedish STD outpatient clinic","volume":"12","author":"Falk","year":"2001","journal-title":"Int J STD AIDS"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91411-e"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1136\/sti.69.4.265"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1086\/367992"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199705000-00009"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00003-06"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3201\/eid1207.051558"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1136\/sti.79.4.318"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4993-4998.2005"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv194"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-11"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1041-6"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2005.018598"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000830"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13305"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.397"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.8.4705-4707.1990"},{"key":"R21","first-page":"124","article-title":"The minimal cellular genome of mycoplasma","volume":"34","author":"Razin","year":"1997","journal-title":"Indian J Biochem Biophys"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2095741"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00889-15"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02513-20"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17972"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000135992.98883.e4"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02124-19"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.3201\/eid2504.181258"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00129-11"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00790-21"},{"key":"R31","volume-title":"Laboratory Biosafety Manual, 4th Edn","year":"2020"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1177\/0956462419825948"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30154-7"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1086\/593188"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ644"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz550"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad057"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab016"},{"key":"R39","first-page":"561","article-title":"Animal models of Mycoplasma genitalium urogenital infection","volume":"23","author":"Taylor-Robinson","year":"1987","journal-title":"Isr J Med Sci"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16511-2"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015660"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05911.x"},{"key":"R43","first-page":"91","article-title":"Intracellular location of Mycoplasma genitalium in cultured vero cells as demonstrated by electron microscopy","volume":"75","author":"Jensen","year":"1994","journal-title":"Int J Exp Pathol"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del455"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01886-19"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10081587"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03147-9"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01023-3"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.02.009"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2017-053384"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328323da3e"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001984?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T15:18:57Z","timestamp":1743779937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.001984"}},"subtitle":["This article is part of the JMM Profiles collection."],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,4]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.001984","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}