{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:15:30Z","timestamp":1790990130615,"version":"4.1.0"},"reference-count":30,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Province Medical and Health Young and Middle-aged training","award":["2023GGB08"],"award-info":[{"award-number":["2023GGB08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> In recent years, with the increase of drug resistance of <jats:italic>Candida<\/jats:italic>, the incidence rate and mortality of candidemia have gradually increased, which has brought a huge economic and health burden to people.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Gap Statement.<\/jats:bold> The epidemiological characteristics and antifungal drug sensitivity patterns in different regions have varied.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim.<\/jats:bold> To analyse the distribution and antifungal susceptibility of <jats:italic>Candida<\/jats:italic> strains isolated from bloodstreams and provide a basis for the use of antifungal drugs for treatment.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> A total of 115 strains of <jats:italic>Candida<\/jats:italic> were collected from the bloodstream, and 28 strains of colonized <jats:italic>Candida albicans<\/jats:italic> were collected from the upper respiratory tract. <jats:italic>Candida<\/jats:italic> species were identified using matrix-assisted laser desorption\/ionization time-of-flight technology. Antifungal susceptibility was assessed using broth microdilution combined with redox methods.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> There were eight types of <jats:italic>Candida<\/jats:italic> strains isolated from the bloodstream; <jats:italic>C. albicans<\/jats:italic> was the most common species (36.5%), followed by <jats:italic>Candida parapsilosis<\/jats:italic> (24.3%), <jats:italic>Candida glabrata<\/jats:italic> (17.4%) and <jats:italic>Candida tropicalis<\/jats:italic> (14.8%). There was no significant difference in the resistance of <jats:italic>C. albicans<\/jats:italic> to azole drugs between the bloodstream infection group and the upper respiratory tract colonization group, but there was a significant difference in the MIC values of micafungin and fluconazole, with <jats:italic>P<\/jats:italic> values of 0.017 and 0.003, respectively. Amphotericin B and echinocandins are the most susceptible drugs for all <jats:italic>Candida<\/jats:italic> species, but the MICs of echinocandins against <jats:italic>C. parapsilosis<\/jats:italic> are significantly higher than those of other <jats:italic>Candida<\/jats:italic> species. <jats:italic>Candida<\/jats:italic> (except for <jats:italic>C. glabrata<\/jats:italic>) is highly resistant to azoles, with <jats:italic>C. parapsilosis<\/jats:italic> showing resistance rates of 89.3% and 82.1% to itraconazole and posaconazole, respectively; the resistance rates of <jats:italic>C. tropicalis<\/jats:italic> are 100% and 94.1%, respectively.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold>\n                  <jats:italic>C. albicans<\/jats:italic> remains the predominant pathogen responsible for candidemia. Although the resistance of <jats:italic>Candida<\/jats:italic> to antifungals is relatively stable, there are significant differences in the MICs of antifungal drugs against <jats:italic>Candida<\/jats:italic>, indicating the importance of strain identification in the treatment of candidemia. For empirical treatment, the use of echinocandin drugs is recommended.<\/jats:p>","DOI":"10.1099\/jmm.0.002011","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T16:16:33Z","timestamp":1747066593000},"source":"Crossref","is-referenced-by-count":3,"title":["In vitro susceptibility profiles of invasive Candida bloodstream isolates to ten antifungal drugs in a southern area of China"],"prefix":"10.1099","volume":"74","author":[{"given":"Qian-Yu","family":"Sang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Xiamen 361000, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Xiamen 361000, PR 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