{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:15:20Z","timestamp":1762982120153,"version":"3.41.0"},"reference-count":32,"publisher":"Microbiology Society","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,16]]},"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) patients may present with a wide clinical spectrum, including extrapulmonary involvement, such as neurological damage. Although the pathogenesis of neurological COVID-19 still remains unclear, some studies have discussed the potential association between tissue injury and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection in the central nervous system (CNS) and\/or immune imbalance. These two mechanisms are non-mutually exclusive; however, exacerbated inflammatory-response-induced neurological damage appears to be more aligned with COVID-19 pathogenesis, whereas SARS-CoV-2 infection\/replication in the CNS remains widely discussed. Herein, we dissect this last issue, highlighting some evidence on SARS-CoV-2 neuroinvasion, as well as discussing gaps that should be addressed for a better understanding of its potential neurotropism, specifically in the CNS. Finally, we propose some deeper reflections on the SARS-CoV-2 neurotropic potential.<\/jats:p>","DOI":"10.1099\/jmm.0.002016","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:16:32Z","timestamp":1750090592000},"source":"Crossref","is-referenced-by-count":1,"title":["SARS-CoV-2 and neurotropism: evidence, gaps and reflections"],"prefix":"10.1099","volume":"74","author":[{"given":"Tha\u00edsa Regina Rocha","family":"Lopes","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Veterin\u00e1ria, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil"},{"name":"Setor de Virologia, Departamento de Medicina Veterin\u00e1ria Preventiva, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana Santana","family":"Sitton","sequence":"additional","affiliation":[{"name":"Programa de 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