{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:40:47Z","timestamp":1757616047031,"version":"3.44.0"},"reference-count":25,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hangzhou Biomedical and Health Industry Development Support Technology Special Project","award":["2023WJC193"],"award-info":[{"award-number":["2023WJC193"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,5]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold>\n                  <jats:italic>Talaromyces marneffei<\/jats:italic> (TM) is a common opportunistic infection among patients with AIDS, characterized by rapid systemic dissemination and a high mortality rate. Early identification of patients at risk of death is critical to improving clinical outcomes.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Hypothesis\/Gap Statement.<\/jats:bold> Despite the severity of disseminated TM infection (DPSM), few predictive tools exist to assess mortality risk in affected AIDS patients. A clinical prediction model incorporating novel inflammatory markers may help guide timely intervention.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim.<\/jats:bold> This study aimed to identify independent risk factors for mortality in AIDS patients with DPSM and to develop and validate a nomogram for individualized risk prediction.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methodology.<\/jats:bold> A retrospective study was conducted on 174 AIDS patients with DPSM and complete clinical data admitted to Hangzhou Xixi Hospital between January 2013 and June 2024. A training cohort of 104\u2009patients was used to identify mortality-related risk factors via logistic regression and to construct a predictive nomogram. The remaining 70\u2009patients constituted a validation cohort to evaluate the model using area under the curve (AUC), decision curve analysis (DCA) and calibration curves.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> The overall mortality rate was 18.97% (33\/174). Effusion, bone marrow suppression, systemic inflammation and malnutrition were significantly associated with fatal outcomes (<jats:italic>P<\/jats:italic>&lt;0.05). Multivariate logistic regression identified white blood cell count, C-reactive protein-to-prealbumin ratio and procalcitonin-to-albumin ratio as independent risk factors for mortality. The nomogram based on these predictors showed strong discriminative power in both training and validation cohorts (AUC=0.89\u2009and 0.78, respectively). DCA demonstrated the clinical utility and net benefit of the model.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> This study identified key predictors of mortality in AIDS patients with DPSM and developed a validated nomogram incorporating novel inflammatory markers. The tool offers potential value for individualized risk assessment and clinical decision-making.<\/jats:p>","DOI":"10.1099\/jmm.0.002066","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:16:33Z","timestamp":1757092593000},"source":"Crossref","is-referenced-by-count":0,"title":["Enhancing mortality prediction in AIDS and disseminated Talaromyces marneffei: the impact of novel inflammatory markers in a nomogram"],"prefix":"10.1099","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-6929","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Open Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaizhong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-019-00410-2"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8020200"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000345"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.18"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S432697"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00051-22"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-017-0592-7"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.05.546"},{"key":"R9","first-page":"1","article-title":"Revised surveillance case definition for HIV infection--united states, 2014","volume":"63","year":"2014","journal-title":"MMWR Recomm Rep"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02236-3"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32560"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-464"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-021-01679-6"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4376-6"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.1.63"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34024"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-05978-z"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.741061"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26823"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27870"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.584461"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-12-30"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1072"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.03.025"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.3352\/jeehp.2013.10.12"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.002066?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:16:34Z","timestamp":1757092594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.002066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,5]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.002066","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"type":"print","value":"0022-2615"},{"type":"electronic","value":"1473-5644"}],"subject":[],"published":{"date-parts":[[2025,9,5]]}}}