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Despite lacking morphological plasticity,\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    employs distinct virulence strategies, including adhesin-mediated host colonization, intracellular survival within phagocytes, stress tolerance, iron acquisition and biofilm formation. This review synthesizes current knowledge of\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    virulence and antifungal resistance mechanisms, with a particular focus on azole and echinocandin resistance driven by efflux pump regulation and\n                    <jats:italic>FKS<\/jats:italic>\n                    mutations. We critically evaluate the greater wax moth larva,\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    , as a non-mammalian\n                    <jats:italic>in vivo<\/jats:italic>\n                    model for studying\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    pathogenesis, host\u2013pathogen interactions and antifungal efficacy. Evidence demonstrating concordance between\n                    <jats:italic>G. mellonella<\/jats:italic>\n                    , murine models and clinical outcomes is discussed, alongside the model\u2019s limitations, including the absence of adaptive immunity. Collectively, this review highlights\n                    <jats:italic>G. mellonella<\/jats:italic>\n                    as a robust, cost-effective platform for dissecting\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    virulence traits and for preclinical screening of antifungal therapies, supporting its growing role in translational fungal research.\n                  <\/jats:p>","DOI":"10.1099\/jmm.0.002127","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:17:42Z","timestamp":1771427862000},"source":"Crossref","is-referenced-by-count":1,"title":["Galleria mellonella as a versatile model for investigating Candida glabrata virulence and antifungal resistance"],"prefix":"10.1099","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7007-3789","authenticated-orcid":false,"given":"Charlie J. 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