{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:32:02Z","timestamp":1788021122290,"version":"build-2784847793"},"reference-count":16,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:p>\n                  <jats:italic>Rickettsia conorii<\/jats:italic> infection is endemic in the Mediterranean basin, where it is known as Mediterranean spotted fever, also known as Boutonneuse fever and Marseilles fever. We report the case of a 66-year-old diabetic man who presented a severe form of the disease, complicated by acute renal failure, thrombocytopenia and encephalitis. Diagnosis was confirmed by indirect immunofluorescence assay. Despite appropriate treatment, severe neurological sequelae have remained. Medical literature on encephalitis caused by <jats:italic>R. conorii<\/jats:italic> is also reviewed.<\/jats:p>","DOI":"10.1099\/jmm.0.004465-0","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T19:18:01Z","timestamp":1236626281000},"page":"521-525","source":"Crossref","is-referenced-by-count":29,"title":["Mediterranean spotted fever with encephalitis"],"prefix":"10.1099","volume":"58","author":[{"given":"Luis","family":"Aliaga","sequence":"first","affiliation":[{"name":"Faculty of Medicine (University of Granada), Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s\/n, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"S\u00e1nchez-Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (University of Granada), Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s\/n, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rodr\u00edguez-Granger","sequence":"additional","affiliation":[{"name":"Service of Microbiology, Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s\/n, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sampedro","sequence":"additional","affiliation":[{"name":"Service of Microbiology, Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s\/n, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Orozco","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (University of Granada), Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s\/n, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pastor","sequence":"additional","affiliation":[{"name":"Service of Radiology, Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, s\/n, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1749-6632.2003.tb07384.x","article-title":"Report of eight cases of fatal and severe Mediterranean spotted fever in Portugal","volume":"990","author":"Amaro","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"R2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/AAC.34.5.937","article-title":"Randomized trial of doxycycline versus josamycin for Mediterranean spotted fever","volume":"34","author":"Bella","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"R3","first-page":"635","article-title":"Fi\u00e8vre Boutonneuse m\u00e9diterran\u00e9enne r\u00e9v\u00e9l\u00e9e par une atteinte neurologique grave","volume":"48","author":"Benhammou","year":"1991","journal-title":"Arch Fr Pediatr"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1469-0691.2004.01019.x","article-title":"Guidelines for the diagnosis of tick-borne bacterial diseases in Europe","volume":"10","author":"Brouqui","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"R5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1086\/313604","article-title":"Minocycline versus doxyxycline in the treatment of Lyme neuroborreliosis","volume":"30","author":"Cunha","year":"2000","journal-title":"Clin Infect Dis"},{"key":"R6","first-page":"38","article-title":"Complicaciones neurol\u00f3gicas de la Fiebre Botonosa Mediterr\u00e1nea. 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Aspectos etiopatog\u00e9nicos, cl\u00ednicos y diagn\u00f3sticos","volume":"9","author":"Marcos Dolado","year":"1994","journal-title":"Neurologia"},{"key":"R10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.4269\/ajtmh.1986.35.845","article-title":"Mediterranean spotted fever: clinical, laboratory and epidemiological features of 199 cases","volume":"35","author":"Raoult","year":"1986","journal-title":"Am J Trop Med Hyg"},{"key":"R11","first-page":"51","article-title":"Fi\u00e8vre boutonneuse m\u00e9diterran\u00e9enne. A propos d'un cas mortel chez un nouveau-n\u00e9","volume":"41","author":"Texier","year":"1984","journal-title":"Arch Fr Pediatr"},{"key":"R12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/589747","article-title":"The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"47","author":"Tunkel","year":"2008","journal-title":"Clin Infect Dis"},{"key":"R13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1099\/jmm.0.46337-0","article-title":"Severe case of Mediterranean spotted fever in Greece with predominant neurological features","volume":"55","author":"Tzavella","year":"2006","journal-title":"J Med Microbiol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4269\/ajtmh.1985.34.361","article-title":"Correlation of the distribution of Rickettsia conorii microscopic lesions, and clinical features in South African tick bite fever","volume":"34","author":"Walker","year":"1985","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"R15","first-page":"2035","article-title":"Rickettsia rickettsi and other spotted fever group rickettsiae (Rocky Mountain spotted fever and other spotted fevers). 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