{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T17:57:36Z","timestamp":1709229456272},"reference-count":14,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>Zygomycosis and aspergillosis are two serious opportunistic fungal infections that are commonly seen in immunocompromised patients. Since both these fungi invade vessels of the arterial system, an early and rapid diagnosis by direct examination of KOH mounts of the relevant clinical sample can confirm the diagnosis. Here, we present an unusual case of a diabetic patient who presented with nasal blockade and bleeding for 2\u2005months, along with occasional haemoptysis for 15\u2005days. On investigation, the patient was diagnosed with a case of rhinocerebral zygomycosis and was treated with amphotericin B (1\u2005mg\u2005kg<jats:sup>\u22121<\/jats:sup>\u2005day<jats:sup>\u22121<\/jats:sup>), which was subsequently replaced with liposomal amphotericin B (2\u2005mg\u2005kg<jats:sup>\u22121<\/jats:sup>\u2005day<jats:sup>\u22121<\/jats:sup>). However, the patient did not completely respond to therapy as haemoptysis continued. Further investigations revealed the presence of <jats:italic>Aspergillus flavus<\/jats:italic> in respiratory specimens. Thus, a final diagnosis of rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient was made, but due to infection of two vital sites by these fungi, the patient could not be saved.<\/jats:p>","DOI":"10.1099\/jmm.0.005272-0","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T19:33:05Z","timestamp":1229110385000},"page":"146-150","source":"Crossref","is-referenced-by-count":5,"title":["Rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient: an unusual case report from India"],"prefix":"10.1099","volume":"58","author":[{"given":"Shalini","family":"Malhotra","sequence":"first","affiliation":[{"name":"Department of Microbiology, Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Duggal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmaljeet Kaur","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charoo","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1288\/00005537-198408000-00013","article-title":"Twenty-five years' experience treating cerebro-rhino-orbital mucormycosis","volume":"94","author":"Abedi","year":"1984","journal-title":"Laryngoscope"},{"key":"R2","first-page":"855","article-title":"Aspergillosis","volume-title":"In Harrison's Principles of Internal Medicine","author":"Bennett","year":"2005"},{"key":"R3","article-title":"Mixed Cryptococcus neoformansand Aspergillus fumigatuscellulitis as primary presentation in an immunocompromised adult","author":"Buenconsejo","year":"2002","journal-title":"Paper presented during the 24th PSMID Annual Convention. 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