{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:47:52Z","timestamp":1761155272304},"reference-count":44,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>Inhalational anthrax is the most severe form of anthrax. It has been shown in small-animal and non-human primate models that relatively large pools of ungerminated<jats:italic>Bacillus anthracis<\/jats:italic>spores can remain within the alveolar spaces for days to weeks post-inhalation or until transported to areas more favourable for germination and bacillary outgrowth. In this study, spores of the Ames strain that were exposed to germination-inducing media prior to intranasal delivery were significantly less infectious than spores delivered in either water or germination-inhibitory medium. The effect of manipulating the germination potential of these spores within the lungs of infected mice by exogenous germination-altering media was examined. The data suggested that neither inducing germination nor inhibiting germination of spores within the lungs protected mice from the ensuing infection. Germination-altering strategies could, instead, significantly increase the severity of disease in a mouse model of inhalational anthrax when implemented<jats:italic>in vivo<\/jats:italic>. It was shown that germination-altering strategies, in this study, were not beneficial to the infected host and are impractical as<jats:italic>in vivo<\/jats:italic>countermeasures.<\/jats:p>","DOI":"10.1099\/jmm.0.008656-0","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T17:23:51Z","timestamp":1241803431000},"page":"816-825","source":"Crossref","is-referenced-by-count":26,"title":["Effects of altering the germination potential of Bacillus anthracis spores by exogenous means in a mouse model"],"prefix":"10.1099","volume":"58","author":[{"given":"C. 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