{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:38:19Z","timestamp":1782603499615,"version":"3.54.5"},"reference-count":7,"publisher":"Microbiology Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>\n                  <jats:italic>Clostridium difficile<\/jats:italic> is a well-known cause of hospital-acquired infection such as antibiotic associated diarrhoea or pseudomembranous colitis. Extraintestinal infections caused by this pathogen are described rarely. A case of post-traumatic wound infection caused by <jats:italic>C. difficile<\/jats:italic> in an immunocompetent, young and otherwise healthy trauma patient is reported. A 31-year-old female, a car accident victim, was admitted to hospital because of polytrauma. After open reduction and internal fixation of a supracondylar femoral fracture by means of the dynamic condylar screw (DCS) system, a purulent fistula occurred. Microbiological examination of the pus revealed <jats:italic>C. difficile<\/jats:italic> as the single aetiological factor of this infection. Empirical antibiotic treatment with cefazoline and metronidazole had been administered right after the surgery, but was found to be ineffective. The strain isolated from the patient was sensitive to most antimicrobials except for clindamycin, and amoxicillin\/clavulanic acid was chosen for the guided therapy. Such treatment combined with the removal of the DCS system produced a desirable effect.<\/jats:p>","DOI":"10.1099\/jmm.0.008797-0","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T17:47:00Z","timestamp":1244742420000},"page":"963-964","source":"Crossref","is-referenced-by-count":12,"title":["Toxin A-producing Clostridium difficile as an aetiological factor of post-traumatic wound infection"],"prefix":"10.1099","volume":"58","author":[{"given":"Aleksander","family":"Deptu\u0142a","sequence":"first","affiliation":[{"name":"Department of Microbiology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kruszy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Mikucka","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Gospodarek","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kruczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"M\u0105tewski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. M. Sk\u0142odowskiej-Curie 9, 85094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0002-9343(03)00184-0","article-title":"Recurrent extraintestinal Clostridium difficile infection","volume":"114","author":"Bedimo","year":"2003","journal-title":"Am J Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1469-0691.2001.00313.x","article-title":"Extra-intestinal infections caused by Clostridium difficile","volume":"7","author":"Garcia-Lechuz","year":"2001","journal-title":"Clin Microbiol Infect"},{"key":"R3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/JCM.41.1.509-511.2003","article-title":"Clostridium difficile brain empyema after prolonged intestinal carriage","volume":"41","author":"Gravisse","year":"2003","journal-title":"J Clin Microbiol"},{"key":"R4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10156-007-0568-X","article-title":"Surgical-site infection with toxin A-nonproducing and toxin B-producing Clostridium difficile","volume":"14","author":"Kikkawa","year":"2008","journal-title":"J Infect Chemother"},{"key":"R5","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1128\/JCM.00524-08","article-title":"Metronidazole resistance in Clostridium difficile is heterogeneous","volume":"46","author":"Pel\u00e1ez","year":"2008","journal-title":"J Clin Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/jcp.49.2.172","article-title":"Nosocomial empyema caused by Clostridium difficile","volume":"49","author":"Simpson","year":"1996","journal-title":"J Clin Pathol"},{"key":"R7","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1099\/jmm.0.47738-0","article-title":"Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe","volume":"57","author":"Spigaglia","year":"2008","journal-title":"J Med Microbiol"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.008797-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T07:26:41Z","timestamp":1601278001000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.008797-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,1]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.008797-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,1]]}}}