{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:15:50Z","timestamp":1761894950275},"reference-count":21,"publisher":"Microbiology Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:p>Several recent reports have suggested that community-associated meticillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) clones, particularly those harbouring genes for Panton\u2013Valentine leukocidin (PVL) or toxic shock syndrome toxin 1 (TSST-1), are increasingly responsible for infections in hospitals. Here, a retrospective study was carried out to investigate whether antimicrobial resistance patterns could be used to detect these pathogens in a French university hospital. Isolates were characterized by antimicrobial susceptibility testing, PCR profiling (PVL genes and <jats:italic>tst<\/jats:italic>), PFGE typing and multilocus sequence typing. Demographic and clinical data were collected from all patients. For PVL-positive MRSA, the typical antimicrobial resistance pattern (susceptible to fluoroquinolones, non-susceptible to fusidic acid, kanamycin resistant and susceptible to gentamicin and tobramycin) had a sensitivity of 77.8\u200a% and a positive predictive value (PPV) of 100\u200a%. For <jats:italic>tst<\/jats:italic>-positive MRSA, the antimicrobial resistance pattern (susceptible to fluoroquinolones and non-susceptible to fusidic acid) had a sensitivity of 100\u200a% and a PPV of 72.4\u200a%. These results suggest that phenotypic rules based on antimicrobial resistance patterns are potentially useful for the detection of PVL- and <jats:italic>tst<\/jats:italic>-positive MRSA isolates.<\/jats:p>","DOI":"10.1099\/jmm.0.010116-0","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T16:50:48Z","timestamp":1252687848000},"page":"1337-1340","source":"Crossref","is-referenced-by-count":20,"title":["Usefulness of antimicrobial resistance pattern for detecting PVL- or TSST-1-producing meticillin-resistant Staphylococcus aureus in a French university hospital"],"prefix":"10.1099","volume":"58","author":[{"given":"Houssein","family":"Gbaguidi-Haore","sequence":"first","affiliation":[{"name":"UMR CNRS 6249 Chrono-Environnement, Universit\u00e9 de Franche-Comt\u00e9, Besan\u00e7on, France"},{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re et d'\u00c9pid\u00e9miologie Mol\u00e9culaire, Centre Hospitalier Universitaire Jean Minjoz, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Thouverez","sequence":"additional","affiliation":[{"name":"UMR CNRS 6249 Chrono-Environnement, Universit\u00e9 de Franche-Comt\u00e9, Besan\u00e7on, France"},{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re et d'\u00c9pid\u00e9miologie Mol\u00e9culaire, Centre Hospitalier Universitaire Jean Minjoz, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Couetdic","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Centre Hospitalier Universitaire Jean Minjoz, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Cholley","sequence":"additional","affiliation":[{"name":"UMR CNRS 6249 Chrono-Environnement, Universit\u00e9 de Franche-Comt\u00e9, Besan\u00e7on, France"},{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re et d'\u00c9pid\u00e9miologie Mol\u00e9culaire, Centre Hospitalier Universitaire Jean Minjoz, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Talon","sequence":"additional","affiliation":[{"name":"UMR CNRS 6249 Chrono-Environnement, Universit\u00e9 de Franche-Comt\u00e9, Besan\u00e7on, France"},{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re et d'\u00c9pid\u00e9miologie Mol\u00e9culaire, Centre Hospitalier Universitaire Jean Minjoz, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Bertrand","sequence":"additional","affiliation":[{"name":"UMR CNRS 6249 Chrono-Environnement, Universit\u00e9 de Franche-Comt\u00e9, Besan\u00e7on, France"},{"name":"Service d'Hygi\u00e8ne Hospitali\u00e8re et d'\u00c9pid\u00e9miologie Mol\u00e9culaire, Centre Hospitalier Universitaire Jean Minjoz, Besan\u00e7on, 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