{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:45:53Z","timestamp":1791107153421,"version":"4.1.0"},"reference-count":27,"publisher":"Microbiology Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:p>\n                    We report a case of community-acquired meticillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5\/12), disseminated disease (4\/12), cavernous sinus thrombosis (2\/12) and other (1\/12). Infection origins were superficial skin infections (5\/12), mostly of the face, sinusitis (1\/12), otitis media (1\/12), other or unknown (5\/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA.\n                  <\/jats:p>","DOI":"10.1099\/jmm.0.011130-0","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T10:38:32Z","timestamp":1250073512000},"page":"1247-1251","source":"Crossref","is-referenced-by-count":45,"title":["Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus"],"prefix":"10.1099","volume":"58","author":[{"given":"Reinout","family":"Naesens","sequence":"first","affiliation":[{"name":"Laboratory of Medical Microbiology, GZA Hospitals, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ronsyn","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, GZA Hospitals, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Druw\u00e9","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, GZA Hospitals, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Denis","sequence":"additional","affiliation":[{"name":"Laboratoire de R\u00e9f\u00e9rence MRSA\u2013Staphylocoques, Department of Microbiology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta","family":"Ieven","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Microbiology, University Hospital Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Jeurissen","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Microbiology, GZA Hospitals, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1258\/002221502760237920","article-title":"Septic cavernous sinus thrombosis secondary to sinusitis: are anticoagulants indicated? 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