{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:22:08Z","timestamp":1759990928035},"reference-count":33,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:p>Delayed and reversible hearing loss occurred in a 55-year-old male patient with murine typhus infection. The patient had the initial symptoms of headache, fever and chills, followed by the occurrence of bilateral hearing loss on day 9 from fever onset. Murine typhus was diagnosed with a high IgM titre by indirect immunofluorescence assay. After treatment with azithromycin and prednisolone, the fever and other symptoms subsided gradually and bilateral hearing loss improved 3 weeks later. Though an adverse reaction to azithromycin could not be ruled out, delayed onset of hearing loss was more likely a complication of murine typhus, mainly because the hearing loss did not occur during the azithromycin usage period. Although hearing loss due to murine typhus is rare, clinicians should be alert to the existence of such a delayed complication.<\/jats:p>","DOI":"10.1099\/jmm.0.013813-0","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T02:52:20Z","timestamp":1264733540000},"page":"602-606","source":"Crossref","is-referenced-by-count":5,"title":["Reversible hearing impairment: delayed complication of murine typhus or adverse reaction to azithromycin?"],"prefix":"10.1099","volume":"59","author":[{"given":"Shang-Yi","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Fen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"},{"name":"Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tun-Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"},{"name":"Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Hsu","family":"Chen","sequence":"additional","affiliation":[{"name":"Tropical Medicine Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"},{"name":"Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"},{"name":"Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Liang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"},{"name":"Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC"},{"name":"College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"},{"name":"Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/clinids\/20.5.1122","article-title":"Long-term sequelae of Rocky Mountain spotted fever","volume":"20","author":"Archibald","year":"1995","journal-title":"Clin Infect Dis"},{"key":"R2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/archinte.159.8.872","article-title":"Murine typhus as a common cause of fever of intermediate duration: a 17-year study in the south of Spain","volume":"159","author":"Bernabeu-Wittel","year":"1999","journal-title":"Arch Intern Med"},{"key":"R3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1128\/AAC.41.1.141","article-title":"Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia rickettsii infection in dogs","volume":"41","author":"Breitschwerdt","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"R4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.7326\/0003-4819-104-2-285_1","article-title":"Hearing loss in Rocky Mountain spotted fever","volume":"104","author":"Dolan","year":"1986","journal-title":"Ann Intern Med"},{"key":"R5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1128\/JB.74.4.432-438.1957","article-title":"Effects of cortisone on experimental murine typhus. 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