{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:59:48Z","timestamp":1761807588852},"reference-count":19,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>A case of prepatellar bursitis in a man with chronic brucellosis is presented. <jats:italic>Brucella abortus<\/jats:italic> biotype 1 was isolated from the abundant yellowish fluid obtained from the bursa. Clinical and epidemiological data did not suggest a direct inoculation of the agent in the bursa. However, the patient mentioned occasional local trauma due to recreational sports, which may have constituted a predisposing factor. As determined by ELISA, there were higher levels of IgG against <jats:italic>Brucella<\/jats:italic> LPS and cytosolic proteins detected in the patient's bursal synovial fluid when compared with serum. Levels of proinflammatory cytokines (tumour necrosis factor alpha, interleukin 1 beta, gamma interferon, interleukin 8 and MCP-1) were higher than in synovial fluids obtained from patients with rheumatoid arthritis and a patient with septic arthritis, and a zymographic analysis revealed a gelatinase of about 92\u2005kDa. These findings indicate that it may be possible to diagnose brucellar bursitis by measuring specific antibodies in the bursal synovial fluid. In addition, our findings suggest a role of increased local levels of proinflammatory cytokines and gelatinases in the inflammatory manifestations of brucellar bursitis.<\/jats:p>","DOI":"10.1099\/jmm.0.016360-0","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T02:25:20Z","timestamp":1282271120000},"page":"1514-1518","source":"Crossref","is-referenced-by-count":18,"title":["Prepatellar bursitis due to Brucella abortus: case report and analysis of the local immune response"],"prefix":"10.1099","volume":"59","author":[{"given":"Jorge C.","family":"Wallach","sequence":"first","affiliation":[{"name":"Servicio de Brucelosis, Hospital F. J. Mu\u00f1iz, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Victoria","family":"Delpino","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU), Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Scian","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU), Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Deodato","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda, Hospital F. J. 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