{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:02:49Z","timestamp":1790665369791,"version":"4.1.0"},"reference-count":20,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:p>\n                  <jats:italic>Mycoplasma hominis<\/jats:italic>, the first mycoplasma of human origin to be isolated, has been associated with several diseases, notably bacterial vaginosis, pelvic inflammatory disease, prematurity and puerperal fever. The mouse model does not mimic closely these features of human disease, but has some notable features. Given intravaginally to mice, <jats:italic>M. hominis<\/jats:italic> does not colonize unless the mice have been pre-treated with oestradiol. As shown here, endogenous hormone has no part to play because removal of the ovaries does not interfere with vaginal colonization. Persistent colonization occurs in hysterectomized mice so that organisms in the upper tract, which are sometimes found, are not responsible, by retrograde leakage, for those in the lower tract. Organisms in the lower tract can be eliminated by treating mice with a tetracycline, or progesterone or by natural resolution. Elimination by whatever means results in a rather weak immunity to recolonization. In contrast, intravenous inoculation of viable, and particularly killed, <jats:italic>M. hominis<\/jats:italic> organisms results in strong resistance to recolonization. This is, in part, genetically influenced, being seen in mice of strain BALB\/c but not of strain CBA. Resistance is inversely proportional to the presence and titre of <jats:italic>M. hominis<\/jats:italic> specific serum antibody. The possible role of cell-mediated immunity is discussed.<\/jats:p>","DOI":"10.1099\/jmm.0.019281-0","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T01:11:40Z","timestamp":1273194700000},"page":"970-975","source":"Crossref","is-referenced-by-count":6,"title":["Further observations on the murine model of Mycoplasma hominis infection"],"prefix":"10.1099","volume":"59","author":[{"given":"David","family":"Taylor-Robinson","sequence":"first","affiliation":[{"name":"Division of Medicine, Imperial College London, St Mary's Campus, Paddington, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Furr","sequence":"additional","affiliation":[{"name":"Division of Medicine, Imperial College London, St Mary's Campus, Paddington, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3181\/00379727-36-9380","article-title":"Observations on the L-organism of Klieneberger","volume":"36","author":"Dienes","year":"1937","journal-title":"Proc Soc Exp Biol Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0022172400064147","article-title":"Enhancement of experimental Mycoplasma pulmonis infection of the mouse genital tract by progesterone","volume":"92","author":"Furr","year":"1984","journal-title":"J Hyg (Lond)"},{"key":"R3","first-page":"2743","article-title":"Oestradiol-induced infection of the genital tract of female mice by Mycoplasma hominis","volume":"135","author":"Furr","year":"1989","journal-title":"J Gen Microbiol"},{"key":"R4","first-page":"141","article-title":"The influence of hormones on the bacterial flora of the murine vagina and implications for human disease","volume":"4","author":"Furr","year":"1991","journal-title":"Microb Ecol Health Dis"},{"key":"R5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1099\/00222615-38-3-160","article-title":"The contrasting effects of progesterone and oestrogen on the susceptibility of mice to genital infection with Mycoplasma pulmonis","volume":"38","author":"Furr","year":"1993","journal-title":"J Med Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2613.1999.00095.x","article-title":"Colonization of the respiratory and genital tracts of female mice with Mycoplasma pneumoniae and protection afforded to the genital tract by prior respiratory colonization","volume":"80","author":"Furr","year":"1999","journal-title":"Int J Exp Pathol"},{"key":"R7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/ard.53.3.183","article-title":"Mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and their role in arthritis: microbiological observations over twenty years","volume":"53","author":"Furr","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"R8","first-page":"131","article-title":"Site of localization of Mycoplasma pulmonis and Mycoplasma hominis in the genital tract of female mice demonstrated by culture and scanning and immuno-electron microscopy","volume":"76","author":"Furr","year":"1995","journal-title":"Int J Exp Pathol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1099\/00221287-50-3-465","article-title":"Haemadsorption and haemagglutination by mycoplasmas","volume":"50","author":"Manchee","year":"1968","journal-title":"J Gen Microbiol"},{"key":"R10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.aje.a120627","article-title":"A color test for the measurement of antibody to the non-acid-forming human Mycoplasma species","volume":"84","author":"Purcell","year":"1966","journal-title":"Am J Epidemiol"},{"key":"R11","first-page":"3.7","volume-title":"Immunology","author":"Roitt","year":"1985"},{"key":"R12","first-page":"38","article-title":"The Mouse. Its Reproduction and Development","author":"Rugh","year":"1968"},{"key":"R13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/clinids\/23.4.671","article-title":"Infections due to Mycoplasma and Ureaplasma : an update","volume":"23","author":"Taylor-Robinson","year":"1996","journal-title":"Clin Infect Dis"},{"key":"R14","first-page":"648","article-title":"Recovery and identification of human genital tract mycoplasmas","volume":"17","author":"Taylor-Robinson","year":"1981","journal-title":"Isr J Med Sci"},{"key":"R15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0950268800047749","article-title":"Elimination of mycoplasmas from the murine genital tract by hormone treatment","volume":"105","author":"Taylor-Robinson","year":"1990","journal-title":"Epidemiol Infect"},{"key":"R16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1099\/00222615-40-3-197","article-title":"Protection of mice against vaginal colonisation by Mycoplasma pulmonis","volume":"40","author":"Taylor-Robinson","year":"1994","journal-title":"J Med Microbiol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/jac\/45.6.903","article-title":"Observations on the antibiotic treatment of experimentally induced mycoplasmal infections in mice","volume":"45","author":"Taylor-Robinson","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3181\/00379727-118-30049","article-title":"The significance of antibody to Mycoplasma hominis type 1 as measured by indirect hemagglutination","volume":"118","author":"Taylor-Robinson","year":"1965","journal-title":"Proc Soc Exp Biol Med"},{"key":"R19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S0022172400040377","article-title":"A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production","volume":"64","author":"Taylor-Robinson","year":"1966","journal-title":"J Hyg (Lond"},{"key":"R20","first-page":"709","article-title":"Genital mycoplasmas","volume-title":"In Sexually Transmitted Diseases","author":"Totten","year":"2008"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.019281-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T15:18:18Z","timestamp":1601479098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.019281-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,1]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.019281-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,1]]}}}