{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:22:43Z","timestamp":1790554963210,"version":"4.1.0"},"reference-count":22,"publisher":"Microbiology Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>The mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. Some studies on transgenic and\/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. Here, the outcome of infection by a virulent strain of<jats:italic>Leptospira interrogans<\/jats:italic>serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wild-type mouse strains: A, CBA, BALB\/c and C57BL\/6. The end points evaluated in this study were survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were susceptible to lethal leptospirosis. However, these strains developed specific pathologies associated with sublethal leptospirosis. The A and C57BL\/6 strains exhibited a high leptospiral load in kidney samples and the CBA and C57BL\/6 strains developed severe inflammatory lesions, whilst the BALB\/c strain proved to be the most resistant to subclinical leptospirosis.<\/jats:p>","DOI":"10.1099\/jmm.0.021089-0","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T02:11:23Z","timestamp":1276827083000},"page":"1101-1106","source":"Crossref","is-referenced-by-count":33,"title":["Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes"],"prefix":"10.1099","volume":"59","author":[{"given":"Cleiton S.","family":"Santos","sequence":"first","affiliation":[{"name":"Gon\u00e7alo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio O.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adenizar D.","family":"Chagas-Junior","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J. A.","family":"McBride","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via W. C.","family":"McBride","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitermayer G.","family":"Reis","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Bahia, Brazil"},{"name":"Gon\u00e7alo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Athanazio","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1128\/IAI.17.1.67-72.1977","article-title":"Host immunological mechanisms in the resistance of mice to leptospiral infections","volume":"17","author":"Adler","year":"1977","journal-title":"Infect 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Leishmania mexicana amazonensis","volume":"44","author":"Barral-Netto","year":"1987","journal-title":"Acta Trop"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1099\/jmm.0.014050-0","article-title":"An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis","volume":"58","author":"Chagas-Junior","year":"2009","journal-title":"J Med Microbiol"},{"key":"R7","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.4049\/jimmunol.0900506","article-title":"TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans","volume":"183","author":"Chassin","year":"2009","journal-title":"J Immunol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.micpath.2009.05.002","article-title":"Chemokines expression during Leptospira interrogans serovar Copenhageni infection in resistant BALB\/c and susceptible C3H\/HeJ 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