{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:37:08Z","timestamp":1771645028793,"version":"3.50.1"},"reference-count":28,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"Few reports have described the cancer prevalence of peptic ulcer patients with long-term follow-up studies. We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males and 34 females; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment; mean follow-up period of 14.4 years (range 1\u201330 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa. We investigated Helicobacter pylori<\/jats:italic> duodenal ulcer promoter gene A (dupA<\/jats:italic>) using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers. GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test P<\/jats:italic><0.05). dupA<\/jats:italic>-positive H. pylori<\/jats:italic> was detected not only in DU patients (9\/20) but also in GU patients (9\/36). Gastric acid output was significantly larger in quantity in patients with dupA<\/jats:italic>-positive H. pylori<\/jats:italic> than in those with dupA<\/jats:italic>-negative H. pylori<\/jats:italic> (P<\/jats:italic><0.05). The occurrence of GCa was significantly lower in patients with dupA<\/jats:italic>-positive H. pylori<\/jats:italic> and a high BAO level (log-rank test P<\/jats:italic><0.05). DUs, higher acid output and dupA<\/jats:italic>-positive H. pylori<\/jats:italic> were negatively associated with GCa.<\/jats:p>","DOI":"10.1099\/jmm.0.021816-0","type":"journal-article","created":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T04:19:25Z","timestamp":1284092365000},"page":"1484-1489","source":"Crossref","is-referenced-by-count":25,"title":["Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development"],"prefix":"10.1099","volume":"59","author":[{"given":"Shinobu","family":"Imagawa","sequence":"first","affiliation":[{"name":"Department of Medicine and Molecular Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Health Service Center, Hiroshima University, Higashi-Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Translational Research Center, Saitama Medical University International Medical Center, Hidaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, 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