{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:06:39Z","timestamp":1793232399755,"version":"4.5.0"},"reference-count":16,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:p>\n                  <jats:italic>Cardiobacterium valvarum<\/jats:italic> is a newly recognized human pathogen related to infective endocarditis. <jats:italic>Cardiobacterium<\/jats:italic> species are, however, only rarely the aetiology of infective endocarditis. An infective endocarditis case is presented and, additionally, phenotypic and phylogenetic comparison of a further 10 collection strains, representing the two species within the genus, was performed. <jats:italic>C. valvarum<\/jats:italic> was isolated from the blood and DNA was present in valvular tissue (partial 16S rRNA gene analysis) from a 64-year-old man with infective endocarditis of the mitral valve, rupture of chordae and prolapse of pulmonary valves in addition to a fluttering excrescence. A mechanical mitral valve and neochordae were inserted successfully. Phenotypically, the two species within the genus <jats:italic>Cardiobacterium<\/jats:italic> resemble each other greatly. When using the Vitek 2 <jats:italic>Neisseria<\/jats:italic>\u2013<jats:italic>Haemophilus<\/jats:italic> identification card, the reaction for phenylphosphonate was positive for all <jats:italic>Cardiobacterium hominis<\/jats:italic> strains, but negative for all <jats:italic>C. valvarum<\/jats:italic> strains, thereby separating the two species. The two species made up two separate clusters by phylogenetic examination using 16S rRNA gene sequence analysis.<\/jats:p>","DOI":"10.1099\/jmm.0.025353-0","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T01:38:52Z","timestamp":1292549932000},"page":"522-528","source":"Crossref","is-referenced-by-count":25,"title":["Cardiobacterium valvarum infective endocarditis and phenotypic\/molecular characterization of 11 Cardiobacterium species strains"],"prefix":"10.1099","volume":"60","author":[{"given":"Ming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark"},{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E.","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette M.","family":"Bangsborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Herlev University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"H\u00f8jlyng","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Medical Department, Roskilde University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Hesselbjerg","sequence":"additional","affiliation":[{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimtas","family":"Dargis","sequence":"additional","affiliation":[{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J\u00f8rgen","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark"},{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/JCM.44.2.657-658.2006","article-title":"Endocarditis caused by Cardiobacterium valvarum","volume":"44","author":"Bothelo","year":"2006","journal-title":"J Clin Microbiol"},{"key":"R2","article-title":"Referenceprogram for identifikation af klinsk vigtige bakterier, herunder nomenklatur","author":"Bruun","year":"1999"},{"key":"R3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1600-0463.2005.apm_224.x","article-title":"Ribosomal DNA sequencing: experiences from use in the Danish Reference Laboratory for Identification of Bacteria","volume":"113","author":"Christensen","year":"2005","journal-title":"APMIS"},{"key":"R4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.med.48.1.25","article-title":"Infective endocarditis caused by HACEK microorganisms","volume":"48","author":"Das","year":"1997","journal-title":"Annu Rev Med"},{"key":"R5","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/JCM.00400-07","article-title":"Fatal bioprosthetic aortic valve endocarditis due to Cardiobacterium valvarum","volume":"45","author":"Geissd\u00f6rfer","year":"2007","journal-title":"J Clin Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"614","DOI":"10.7326\/0003-4819-143-8-200510180-00016","article-title":"Cardiobacterium valvarum endocarditis","volume":"143","author":"Han","year":"2005","journal-title":"Ann Intern Med"},{"key":"R7","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1128\/JCM.43.5.2370-2374.2005","article-title":"Characterization of oral strains of Cardiobacterium valvarum and emended description of the organism","volume":"43","author":"Han","year":"2005","journal-title":"J Clin Microbiol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1128\/JCM.42.4.1590-1595.2004","article-title":"Endocarditis with ruptured cerebral aneurysm caused by Cardiobacterium valvarum sp","volume":"42","author":"Han","year":"2004","journal-title":"nov. 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