{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:35:30Z","timestamp":1792730130269,"version":"4.5.0"},"reference-count":41,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:p>Cardiac infections caused by the foodborne bacterium<jats:italic>Listeria monocytogenes<\/jats:italic>represent a significant but poorly studied facet of disease. It is not known whether<jats:italic>L. monocytogenes<\/jats:italic>cardiac infections stem solely from host susceptibility, or whether bacterial isolates exist that exhibit a tropism for cardiac tissue. Here we examine the cardio-invasive capacity of a recent<jats:italic>L. monocytogenes<\/jats:italic>cardiac case strain (07PF0776) as well as nine additional outbreak and clinical isolates. Mice infected with the cardiac isolate 07PF0776 had 10-fold more bacteria recovered from heart tissue than those infected with<jats:italic>L. monocytogenes<\/jats:italic>strain 10403S, a well-characterized clinical isolate originally obtained from a human skin lesion. Additional<jats:italic>L. monocytogenes<\/jats:italic>isolates exhibited varied capacities to colonize the hearts of mice; however, those with the highest efficiency of mouse cardiac invasion also demonstrated the highest levels of bacterial invasion in cultured myoblast cells. Our findings strongly suggest that subpopulations of<jats:italic>L. monocytogenes<\/jats:italic>strains have acquired an enhanced ability to target and invade the myocardium.<\/jats:p>","DOI":"10.1099\/jmm.0.027185-0","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T05:06:09Z","timestamp":1296018369000},"page":"423-434","source":"Crossref","is-referenced-by-count":24,"title":["Evidence for subpopulations of Listeria monocytogenes with enhanced invasion of cardiac cells"],"prefix":"10.1099","volume":"60","author":[{"given":"Francis","family":"Alonzo","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda D.","family":"Bobo","sequence":"additional","affiliation":[{"name":"Adult Infectious Diseases, Washington University School of Medicine, St Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Skiest","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Baystate Medical Center \u2013 Tufts University School of Medicine, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Freitag","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jinf.2008.12.007","article-title":"Inflammatory pseudotumor of the heart caused by Listeria monocytogenes infection","volume":"58","author":"Adler","year":"2009","journal-title":"J Infect"},{"key":"R2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1128\/IAI.00280-09","article-title":"The posttranslocation chaperone PrsA2 contributes to multiple facets of Listeria monocytogenes pathogenesis","volume":"77","author":"Alonzo","year":"2009","journal-title":"Infect Immun"},{"key":"R3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejim.2007.06.020","article-title":"Endocarditis due to Listeria : description of two cases and review of the literature","volume":"19","author":"Antol\u00edn","year":"2008","journal-title":"Eur J Intern Med"},{"key":"R4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/clinids\/13.1.115","article-title":"Listeriosis in patients infected with human immunodeficiency virus","volume":"13","author":"Berenguer","year":"1991","journal-title":"Rev Infect Dis"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.micinf.2007.05.003","article-title":"Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes","volume":"9","author":"Bierne","year":"2007","journal-title":"Microbes Infect"},{"key":"R6","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.4049\/jimmunol.139.6.2005","article-title":"Adoptive transfer of immunity to Listeria monocytogenes. 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