{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:41:31Z","timestamp":1792640491022,"version":"4.5.0"},"reference-count":71,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"DOI":"10.1099\/jmm.0.030932-0","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T23:34:26Z","timestamp":1301700866000},"page":"699-709","source":"Crossref","is-referenced-by-count":404,"title":["Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies"],"prefix":"10.1099","volume":"60","author":[{"given":"Maarten","family":"Fauvart","sequence":"first","affiliation":[{"name":"Centre of Microbial and Plant Genetics, K.U.Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie N.","family":"De Groote","sequence":"additional","affiliation":[{"name":"Centre of Microbial and Plant Genetics, K.U.Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Michiels","sequence":"additional","affiliation":[{"name":"Centre of Microbial and Plant Genetics, K.U.Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099390"},{"key":"r2","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.1128\/JB.173.18.5732-5739.1991","article-title":"Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis","volume":"173","author":"Black","year":"1991","journal-title":"J Bacteriol"},{"key":"r3","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/JB.176.13.4081-4091.1994","article-title":"Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis","volume":"176","author":"Black","year":"1994","journal-title":"J Bacteriol"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1126\/science.257.5073.1055"},{"key":"r5","first-page":"99","article-title":"Pathogenesis of cystic fibrosis airways disease","volume":"112","author":"Boucher","year":"2001","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.02.003"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1086\/314727"},{"key":"r8","first-page":"1","article-title":"Clinical strategies for cancer treatment: the role of drugs","volume-title":"Cancer Chemotherapy and Biotherapy: Principles and Practices","author":"Chabner","year":"2006"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8795-8801.2005"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134043"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01237-06"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1089\/10766290152773347"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01657.x"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.019703-0"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-008-0243-6"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.12.007"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000760"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000317"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2453"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.6012-6022.2004"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01218-09"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00156.x"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-505SO"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.4.5.711"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00144-08"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/004077-0"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511546242.008"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.2174\/092986708785747580"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-008-0099-3"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0434-2"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01717.x"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00856-5"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.24.8172-8180.2004"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03779.x"},{"key":"r35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00684-06"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00860-09"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00101.x"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.06.026"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1445"},{"key":"r40","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1557"},{"key":"r41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134306"},{"key":"r42","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00052-07"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.30.100176.002535"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.2.194-222.2002"},{"key":"r45","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01231-09"},{"key":"r46","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1128\/JB.155.2.768-775.1983","article-title":"hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis","volume":"155","author":"Moyed","year":"1983","journal-title":"J Bacteriol"},{"key":"r47","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1128\/JB.166.2.399-403.1986","article-title":"Molecular cloning and expression of hipA, a gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis","volume":"166","author":"Moyed","year":"1986","journal-title":"J Bacteriol"},{"key":"r48","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01651-09"},{"key":"r49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06274.x"},{"key":"r50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2006.00117.x"},{"key":"r51","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27385-0"},{"key":"r52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004333107"},{"key":"r53","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1128\/JB.170.8.3321-3326.1988","article-title":"Conditional impairment of cell division and altered lethality in hipA mutants of Escherichia coli K-12","volume":"170","author":"Scherrer","year":"1988","journal-title":"J Bacteriol"},{"key":"r54","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163806"},{"key":"r55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-6-53"},{"key":"r56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.027"},{"key":"r57","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq103"},{"key":"r58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602138103"},{"key":"r59","doi-asserted-by":"publisher","DOI":"10.1038\/nature08012"},{"key":"r60","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.23.6746-6751.2001"},{"key":"r61","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00369-06"},{"key":"r62","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.009142-0"},{"key":"r63","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/AAC.30.4.521","article-title":"Antibiotic tolerance among clinical isolates of bacteria","volume":"30","author":"Tuomanen","year":"1986","journal-title":"Antimicrob Agents Chemother"},{"key":"r64","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.10.006"},{"key":"r65","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1348-0421.2006.tb03793.x","article-title":"Functional analysis of spoT, relA and dksA genes on quinolone tolerance in Pseudomonas aeruginosa under nongrowing condition","volume":"50","author":"Viducic","year":"2006","journal-title":"Microbiol Immunol"},{"key":"r66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.12.003"},{"key":"r67","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1128\/AAC.43.11.2600","article-title":"Drug tolerance in Mycobacterium tuberculosis","volume":"43","author":"Wallis","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"r68","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.139"},{"key":"r69","volume-title":"WHO Report 2009: Global Tuberculosis Control. Epidemiology, Strategy, Financing","year":"2009"},{"key":"r70","doi-asserted-by":"publisher","DOI":"10.2741\/1291"},{"key":"r71","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.100120"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.030932-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T11:17:31Z","timestamp":1585912651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.030932-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,1]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.030932-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,1]]}}}