{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:46:37Z","timestamp":1793303197278,"version":"4.5.0"},"reference-count":21,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:p>The biosynthesis of chondroitinase and hyaluronidase by different isolates of <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> was investigated in 20 strains isolated from patients (17 strains), a penguin (<jats:italic>Pygocelis adeliae<\/jats:italic>, one strain), an armadillo (<jats:italic>Dasypus novemcinctus<\/jats:italic>, one strain) and the environment (dog food, one strain). All the <jats:italic>P. brasiliensis<\/jats:italic> isolates studied had the ability to produce chondroitinase and hyaluronidase, although differences in colony morphology and enzyme production were detected among them. These results suggest that further investigations should be carried out in the clinical field in order to clarify the potential role of <jats:italic>P. brasiliensis<\/jats:italic> enzyme production in the pathogenesis of paracoccidioidomycosis.<\/jats:p>","DOI":"10.1099\/jmm.0.04933-0","type":"journal-article","created":{"date-parts":[[2003,5,15]],"date-time":"2003-05-15T00:04:17Z","timestamp":1052957057000},"page":"479-481","source":"Crossref","is-referenced-by-count":17,"title":["Biosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis"],"prefix":"10.1099","volume":"52","author":[{"given":"C.  M.","family":"de Assis","sequence":"first","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil 2Departamento de Microbiologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, SP, Brazil 3Faculdade de Odontologia, Universidade Estadual de S\u00e3o Paulo, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil#dReceived 3 April 2002 Accepted 5 February 2003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.  F.","family":"Gandra","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil 2Departamento de Microbiologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, SP, Brazil 3Faculdade de Odontologia, Universidade Estadual de S\u00e3o Paulo, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil#dReceived 3 April 2002 Accepted 5 February 2003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Gambale","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil 2Departamento de Microbiologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, SP, Brazil 3Faculdade de Odontologia, Universidade Estadual de S\u00e3o Paulo, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil#dReceived 3 April 2002 Accepted 5 February 2003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.  T.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil 2Departamento de Microbiologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, SP, Brazil 3Faculdade de Odontologia, Universidade Estadual de S\u00e3o Paulo, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil#dReceived 3 April 2002 Accepted 5 February 2003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.  R.","family":"Paula","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil 2Departamento de Microbiologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, SP, Brazil 3Faculdade de Odontologia, Universidade Estadual de S\u00e3o Paulo, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil#dReceived 3 April 2002 Accepted 5 February 2003"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"H1-6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/02681219380000361","article-title":"Detection of proteolytic enzymes released by the dimorphic fungus P.brasiliensis","volume":"31","author":"Bedoya-Escobar","year":"1993","journal-title":"J Med Vet Mycol"},{"key":"H2-6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0966-842X(01)02292-2","article-title":"The pathobiology of Paracoccidioides brasiliensis","volume":"10","author":"Borges-Walmsley","year":"2002","journal-title":"Trends Microbiol"},{"key":"H3-6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/bj3090209","article-title":"Characterization of an exocellular serine-thiol proteinase activity in Paracoccidioides brasiliensis","volume":"309","author":"Carmona","year":"1995","journal-title":"Biochem J"},{"key":"H4-6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1007022110989","article-title":"Production of proteinase and phospholipase by Paracoccidioides brasiliensis","volume":"146","author":"de Assis","year":"1999","journal-title":"Mycopathologia"},{"key":"H5-6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/02681219080000311","article-title":"Isolation and characterization of a Paracoccidioides brasiliensis strain from a dogfood probably contaminated with soil in Uberl\u00e2ndia","volume":"28","author":"Ferreira","year":"1990","journal-title":"Brazil. 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