{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:05:59Z","timestamp":1791223559058,"version":"4.1.0"},"reference-count":107,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:p><jats:italic>Salmonella enterica<\/jats:italic>serovar Typhi (<jats:italic>S. typhi<\/jats:italic>) causes human typhoid fever, a serious and widespread disease in developing countries. Other<jats:italic>Salmonella<\/jats:italic>serovars are associated with food-borne infections. The recent emergence of multi-drug-resistant<jats:italic>Salmonella<\/jats:italic>strains highlights the need for better preventive measures, including vaccination. The available vaccines against<jats:italic>Salmonella<\/jats:italic>infection do not confer optimal protection. The design of new<jats:italic>Salmonella<\/jats:italic>vaccines must be based on the identification of suitable virulence genes and on knowledge of the immunological mechanisms of resistance to the disease. Control and clearance of a vaccine strain rely on the phagocyte oxidative burst, reactive nitrogen intermediates, inflammatory cytokines and CD4<jats:sup>+<\/jats:sup>TCR-\u03b1\u03b2<jats:sup>+<\/jats:sup>T cells and are controlled by genes including<jats:italic>NRAMP1<\/jats:italic>and MHC class II. Vaccine-induced resistance to reinfection requires the presence of Th1-type immunological memory and anti-<jats:italic>Salmonella<\/jats:italic>antibodies. The interaction between T and B cells is essential for the development of resistance following vaccination. The identification of immunodeficiencies that render individuals more susceptible to salmonellosis must be taken into consideration when designing and testing live attenuated<jats:italic>Salmonella<\/jats:italic>vaccines. An ideal live<jats:italic>Salmonella<\/jats:italic>vaccine should therefore be safe, regardless of the immunological status of the vaccinee, but still immunogenic.<\/jats:p>","DOI":"10.1099\/jmm.0.05173-0","type":"journal-article","created":{"date-parts":[[2003,5,15]],"date-time":"2003-05-15T00:04:17Z","timestamp":1052957057000},"page":"453-459","source":"Crossref","is-referenced-by-count":86,"title":["Development of acquired immunity to Salmonella"],"prefix":"10.1099","volume":"52","author":[{"given":"Pietro","family":"Mastroeni,","sequence":"first","affiliation":[{"name":"Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"M\u00e9nager","sequence":"additional","affiliation":[{"name":"Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"H1-3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1056\/NEJM198710293171801","article-title":"Prevention of typhoid fever in Nepal with the Vi capsular polysaccharide of Salmonella typhi .A preliminary report","volume":"317","author":"Acharya","year":"1987","journal-title":"N Engl J Med"},{"key":"H2-3","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1172\/JCI4950","article-title":"Inherited interleukin 12 deficiency in a child with bacille Calmette\u2013Guerin and Salmonella enteritidis disseminated infection","volume":"102","author":"Altare","year":"1998","journal-title":"J Clin Invest"},{"key":"H3-3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0950268800047440","article-title":"Further studies on the inhibition of colonization of the chicken alimentary tract with Salmonella typhimurium by pre-colonization with an avirulent mutant","volume":"104","author":"Berchieri","year":"1990","journal-title":"Epidemiol Infect"},{"key":"H4-3","first-page":"74","article-title":"The kinetics of blood clearance of isotopically labelled Salmonella enteritidis by the reticuloendothelial system in mice","volume":"3","author":"Biozzi","year":"1960","journal-title":"Immunology"},{"key":"H5-3","first-page":"453","article-title":"Infections in cancer patients.I","volume":"7","author":"Bodey","year":"1974","journal-title":"Bacterial infections. Rev Bras Pesqui Med Biol"},{"key":"H6-3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0882-4010(89)90086-7","article-title":"The antibody response to salmonellae in mice and humans studied by immunoblots and ELISA","volume":"6","author":"Brown","year":"1989","journal-title":"Microb Pathog"},{"key":"H7-3","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1128\/IAI.60.7.2823-2827.1992","article-title":"Construction of a recombinant oral vaccine against Salmonella typhi and Salmonella typhimurium","volume":"60","author":"Cao","year":"1992","journal-title":"Infect Immun"},{"key":"H8-3","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.139.5.1189","article-title":"The route of enteric infection in normal mice","volume":"139","author":"Carter","year":"1974","journal-title":"J Exp Med"},{"key":"H9-3","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1084\/jem.20011547","article-title":"Salmonella pathogenicity island 2 mediates protection of intracellular Salmonella from reactive nitrogen intermediates","volume":"195","author":"Chakravortty","year":"2002","journal-title":"J Exp Med"},{"key":"H10-3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/MMBR.38.4.371-402.1974","article-title":"Vaccines and cell-mediated immunity","volume":"38","author":"Collins","year":"1974","journal-title":"Bacteriol Rev"},{"key":"H11-3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/0140-6736(90)93251-J","article-title":"Epidemiology of foodborne illness: UK","volume":"336","author":"Cooke","year":"1990","journal-title":"Lancet"},{"key":"H12-3","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.4049\/jimmunol.158.9.4310","article-title":"Identification of a natural T cell epitope presented by Salmonella -infected macrophages and recognized by T cells from orally immunized mice","volume":"158","author":"Cookson","year":"1997","journal-title":"J Immunol"},{"key":"H13-3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/vr.138.7.149","article-title":"Evaluation of SEF14 fimbrial dot blot and flagellar western blot tests as indicators of Salmonella enteritidis infection in chickens","volume":"138","author":"Cooper","year":"1996","journal-title":"Vet Rec"},{"key":"H14-3","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1128\/IAI.62.11.4747-4754.1994","article-title":"Vaccination of chickens with strain CVL30, a genetically defined Salmonella enteritidis aroA live oral vaccine candidate","volume":"62","author":"Cooper","year":"1994","journal-title":"Infect Immun"},{"key":"H15-3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1073\/pnas.86.3.825","article-title":"Cytosolic components of the respiratory burst oxidase: resolution of four components, two of which are missing in complementing types of chronic granulomatous disease","volume":"86","author":"Curnutte","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"H16-3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.280.5368.1435","article-title":"Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients","volume":"280","author":"de Jong","year":"1998","journal-title":"Science"},{"key":"H17-3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0882-4010(91)90013-Z","article-title":"A \u2018safe-site\u2019 for Salmonella typhimurium is within splenic cells during the early phase of infection in mice","volume":"10","author":"Dunlap","year":"1991","journal-title":"Microb Pathog"},{"key":"H18-3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1086\/317940","article-title":"Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam","volume":"183","author":"Dunstan","year":"2001a","journal-title":"J Infect Dis"},{"key":"H19-3","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1086\/319289","article-title":"Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1","volume":"183","author":"Dunstan","year":"2001b","journal-title":"J Infect Dis"},{"key":"H20-3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.4049\/jimmunol.133.2.958","article-title":"Cellular immunity induced by avirulent Salmonella in LPS-defective C3H\/HeJ mice","volume":"133","author":"Eisenstein","year":"1984a","journal-title":"J Immunol"},{"key":"H21-3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/infdis\/150.3.425","article-title":"Immunity to infection with Salmonella typhimurium : mouse-strain differences in vaccine- and serum-mediated protection","volume":"150","author":"Eisenstein","year":"1984b","journal-title":"J Infect Dis"},{"key":"H22-3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2567.1998.00492.x","article-title":"Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins","volume":"94","author":"Galdiero","year":"1998","journal-title":"Immunology"},{"key":"H23-3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archinte.1991.00400020125026","article-title":"Association between the acquired immunodeficiency syndrome and infection with Salmonella typhi or Salmonella paratyphi in an endemic typhoid area","volume":"151","author":"Gotuzzo","year":"1991","journal-title":"Arch Intern Med"},{"key":"H24-3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1365-2567.1997.00158.x","article-title":"Correlates of protection induced by live Aro\u2212 Salmonella typhimurium vaccines in the murine typhoid model","volume":"90","author":"Harrison","year":"1997","journal-title":"Immunology"},{"key":"H25-3","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.4049\/jimmunol.156.9.3321","article-title":"Salmonella typhimurium aroA \u2212 infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location","volume":"156","author":"Hess","year":"1996","journal-title":"J Immunol"},{"key":"H26-3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1086\/318457","article-title":"Nontyphoidal salmonellosis","volume":"32","author":"Hohmann","year":"2001","journal-title":"Clin Infect Dis"},{"key":"H27-3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4757-9966-8_17","article-title":"Dendritic cells of the murine Peyer's patches colocalize with Salmonella typhimurium avirulent mutants in the subepithelial dome","volume":"417","author":"Hopkins","year":"1997","journal-title":"Adv Exp Med Biol"},{"key":"H28-3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0882-4010(90)90023-J","article-title":"Dead salmonellae or their endotoxin accelerate the early course of a Salmonella infection in mice","volume":"9","author":"Hormaeche","year":"1990","journal-title":"Microb Pathog"},{"key":"H29-3","first-page":"547","article-title":"Acquired immunity to Salmonella typhimurium and delayed (footpad) hypersensitivity in BALB\/c mice","volume":"43","author":"Hormaeche","year":"1981","journal-title":"Immunology"},{"key":"H30-3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/infdis\/152.5.1050","article-title":"Natural resistance to salmonellae in mice: control by genes within the major histocompatibility complex","volume":"152","author":"Hormaeche","year":"1985","journal-title":"J Infect Dis"},{"key":"H31-3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0882-4010(91)90075-L","article-title":"Immunity conferred by Aro\u2212 Salmonella live vaccines","volume":"10","author":"Hormaeche","year":"1991","journal-title":"Microb Pathog"},{"key":"H32-3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0264-410X(95)00249-Z","article-title":"Protection against oral challenge three months after i.v. immunization of BALB\/c mice with live aro Salmonella typhimurium and Salmonella enteritidis vaccines is serotype (species)-dependent and only partially determined by the main LPS O antigen","volume":"14","author":"Hormaeche","year":"1996","journal-title":"Vaccine"},{"issue":"Suppl. 2","key":"H33-3","first-page":"1","article-title":"Typhoid fever, global situation and WHO recommendations","volume":"26","author":"Ivanhoff","year":"1995","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"H34-3","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/infdis\/153.6.1126","article-title":"Specific immunoglobulin-secreting human blood cells after peroral vaccination against Salmonella typhi","volume":"153","author":"Kantele","year":"1986","journal-title":"J Infect Dis"},{"key":"H35-3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0882-4010(91)90072-I","article-title":"Comparison of the human immune response to live oral, killed oral or killed parenteral Salmonella typhi Ty21a vaccines","volume":"10","author":"Kantele","year":"1991","journal-title":"Microb Pathog"},{"key":"H36-3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.4049\/jimmunol.133.3.1190","article-title":"Differences in delayed-type hypersensitivity responses in various mouse strains in the C3H lineage infected with Salmonella typhimurium , strain SL3235","volume":"133","author":"Killar","year":"1984","journal-title":"J Immunol"},{"key":"H37-3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/IAI.52.2.504-508.1986","article-title":"Delayed-type hypersensitivity and immunity to Salmonella typhimurium","volume":"52","author":"Killar","year":"1986","journal-title":"Infect Immun"},{"key":"H38-3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0264-410X(95)00186-5","article-title":"Immunogenicity, efficacy and serological correlate of protection of Salmonella typhi Vi capsular polysaccharide vaccine three years after immunization","volume":"14","author":"Klugman","year":"1996","journal-title":"Vaccine"},{"key":"H39-3","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1128\/IAI.67.11.5806-5810.1999","article-title":"Safety and immunogenicity of Vi conjugate vaccines for typhoid fever in adults, teenagers, and 2- to 4-year-old children in Vietnam","volume":"67","author":"Kossaczka","year":"1999","journal-title":"Infect Immun"},{"key":"H40-3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1128\/IAI.25.3.857-862.1979","article-title":"Immunization with major outer membrane proteins in experimental salmonellosis of mice","volume":"25","author":"Kuusi","year":"1979","journal-title":"Infect Immun"},{"issue":"Suppl. 3","key":"H41-3","doi-asserted-by":"crossref","first-page":"S552","DOI":"10.1093\/clinids\/11.Supplement_3.S552","article-title":"Progress in vaccines against typhoid fever","volume":"11","author":"Levine","year":"1989","journal-title":"Rev Infect Dis"},{"key":"H42-3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/IAI.41.2.563-569.1983","article-title":"Complement activation by polysaccharide of lipopolysaccharide: an important virulence determinant of salmonellae","volume":"41","author":"Liang-Takasaki","year":"1983","journal-title":"Infect Immun"},{"key":"H43-3","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1056\/NEJM200104263441701","article-title":"The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children","volume":"344","author":"Lin","year":"2001","journal-title":"N Engl J Med"},{"key":"H44-3","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.4049\/jimmunol.162.9.5398","article-title":"T cell responses to Gram-negative intracellular bacterial pathogens: a role for CD8+ T cells in immunity to Salmonella infection and the involvement of MHC class Ib molecules","volume":"162","author":"Lo","year":"1999","journal-title":"J Immunol"},{"key":"H45-3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/72329","article-title":"Molecular mimicry mediated by MHC class Ib molecules after infection with gram-negative pathogens","volume":"6","author":"Lo","year":"2000","journal-title":"Nat Med"},{"key":"H46-3","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1107::AID-IMMU1107>3.0.CO;2-0","article-title":"Salmonella efficiently enter and survive within cultured CD11c+ dendritic cells initiating cytokine expression","volume":"29","author":"Marriott","year":"1999","journal-title":"Eur J Immunol"},{"key":"H47-3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0882-4010(87)90127-6","article-title":"The initial suppression of bacterial growth in a Salmonella infection is mediated by a localized rather than a systemic response","volume":"2","author":"Maskell","year":"1987","journal-title":"Microb Pathog"},{"key":"H48-3","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1128\/IAI.66.10.4767-4776.1998","article-title":"Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB\/c mice: role of gamma interferon and macrophage activation","volume":"66","author":"Mastroeni","year":"1998","journal-title":"Infect Immun"},{"key":"H49-3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/IAI.68.1.46-53.2000","article-title":"Igh-6 \u2212\/\u2212 (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens","volume":"68","author":"Mastroeni","year":"2000a","journal-title":"Infect Immun"},{"key":"H50-3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1084\/jem.192.2.237","article-title":"Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis.II. Effects on microbial proliferation and host survival in vivo","volume":"192","author":"Mastroeni","year":"2000b","journal-title":"J Exp Med"},{"key":"H51-3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1053\/tvjl.2000.0502","article-title":"Salmonella : immune responses and vaccines","volume":"161","author":"Mastroeni","year":"2001","journal-title":"Vet J"},{"key":"H52-3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1348-0421.1989.tb00957.x","article-title":"Protective immunity induced by porin in experimental mouse salmonellosis","volume":"33","author":"Matsui","year":"1989","journal-title":"Microbiol Immunol"},{"key":"H53-3","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/35101614","article-title":"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2","volume":"413","author":"McClelland","year":"2001","journal-title":"Nature"},{"key":"H54-3","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1128\/IAI.68.6.3344-3348.2000","article-title":"Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar Typhimurium","volume":"68","author":"McSorley","year":"2000","journal-title":"Infect Immun"},{"key":"H55-3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.4049\/jimmunol.164.2.986","article-title":"Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium","volume":"164","author":"McSorley","year":"2000","journal-title":"J Immunol"},{"key":"H56-3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1099\/00222615-44-5-317","article-title":"Multi-drug resistant typhoid: a global problem","volume":"44","author":"Mirza","year":"1996","journal-title":"J Med Microbiol"},{"key":"H57-3","doi-asserted-by":"crossref","first-page":"6769","DOI":"10.4049\/jimmunol.163.12.6769","article-title":"Critical role of CD28 in protective immunity against Salmonella typhimurium","volume":"163","author":"Mittrucker","year":"1999","journal-title":"J Immunol"},{"key":"H58-3","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4049\/jimmunol.164.4.1648","article-title":"Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection","volume":"164","author":"Mittrucker","year":"2000","journal-title":"J Immunol"},{"key":"H59-3","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1128\/IAI.62.10.4618-4621.1994","article-title":"Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo","volume":"62","author":"Mixter","year":"1994","journal-title":"Infect Immun"},{"key":"H60-3","first-page":"374","article-title":"Chronic septic granulomatosis.Clinical and therapeutic aspects","volume":"36","author":"Mouy","year":"1989","journal-title":"Ann Pediatr (Paris)"},{"key":"H61-3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1099\/00222615-24-1-11","article-title":"Protection against experimental salmonellosis in mice and sheep by immunisation with aromatic-dependent Salmonella typhimurium","volume":"24","author":"Mukkur","year":"1987","journal-title":"J Med Microbiol"},{"key":"H62-3","first-page":"228","article-title":"Immunity to Salmonella typhi : considerations relevant to measurement of cellular immunity in typhoid-endemic regions","volume":"75","author":"Murphy","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"H63-3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/IAI.60.2.450-454.1992","article-title":"Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection","volume":"60","author":"Nauciel","year":"1992","journal-title":"Infect Immun"},{"key":"H64-3","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1128\/IAI.56.9.2407-2411.1988","article-title":"Role of H-2 and non-H-2 genes in control of bacterial clearance from the spleen in Salmonella typhimurium -infected mice","volume":"56","author":"Nauciel","year":"1988","journal-title":"Infect Immun"},{"key":"H65-3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0008-8749(82)90224-6","article-title":"Defect in macrophage effector function confers Salmonella typhimurium susceptibility on C3H\/HeJ mice","volume":"67","author":"O'Brien","year":"1982","journal-title":"Cell Immunol"},{"key":"H66-3","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1128\/IAI.62.12.5376-5383.1994","article-title":"A Salmonella enteritidis 11RX pilin induces strong T-lymphocyte responses","volume":"62","author":"Ogunniyi","year":"1994","journal-title":"Infect Immun"},{"key":"H67-3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0167-5699(98)01321-8","article-title":"Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria","volume":"19","author":"Ottenhoff","year":"1998","journal-title":"Immunol Today"},{"key":"H68-3","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/35101607","article-title":"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"},{"key":"H69-3","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1128\/IAI.70.8.4009-4018.2002","article-title":"Salmonella enterica serovar Typhi live vector vaccines delivered intranasally elicit regional and systemic specific CD8+ major histocompatibility class I-restricted cytotoxic T lymphocytes","volume":"70","author":"Pasetti","year":"2002","journal-title":"Infect Immun"},{"key":"H70-3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1086\/338625","article-title":"Inherited interleukin-12 deficiency: IL-12B genotype and clinical phenotype of 13 patients from six kindreds","volume":"70","author":"Picard","year":"2002","journal-title":"Am J Hum Genet"},{"key":"H71-3","first-page":"177","article-title":"Induction of Lyt-2+ cytotoxic T lymphocytes following primary and secondary Salmonella infection","volume":"81","author":"Pope","year":"1994","journal-title":"Immunology"},{"key":"H72-3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","article-title":"Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria","volume":"2","author":"Rescigno","year":"2001","journal-title":"Nat Immunol"},{"key":"H73-3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.186.4.569","article-title":"Murine salmonellosis studied by confocal microscopy: Salmonella typhimurium resides intracellularly inside macrophages and exerts a cytotoxic effect on phagocytes in vivo","volume":"186","author":"Richter-Dahlfors","year":"1997","journal-title":"J Exp Med"},{"key":"H74-3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/IAI.37.2.728-736.1982","article-title":"Salmonella typhimurium infection in calves: specific immune reactivity against O-antigenic polysaccharide detectable in in vitro assays","volume":"37","author":"Robertsson","year":"1982a","journal-title":"Infect Immun"},{"key":"H75-3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1128\/IAI.37.2.737-748.1982","article-title":"Salmonella typhimurium infection in calves: delayed specific skin reactions directed against the O-antigenic polysaccharide chain","volume":"37","author":"Robertsson","year":"1982b","journal-title":"Infect Immun"},{"key":"H76-3","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.4049\/jimmunol.169.4.2196","article-title":"Characterization of CD8+ effector T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine","volume":"169","author":"Salerno-Goncalves","year":"2002","journal-title":"J Immunol"},{"key":"H77-3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0882-4010(87)90111-2","article-title":"Alternative complement pathway activation by Salmonella O polysaccharide as a virulence determinant in the mouse","volume":"2","author":"Saxen","year":"1987","journal-title":"Microb Pathog"},{"key":"H78-3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/IAI.60.3.791-797.1992","article-title":"Natural killer cells mediate protection induced by a Salmonella aroA mutant","volume":"60","author":"Schafer","year":"1992","journal-title":"Infect Immun"},{"key":"H79-3","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1128\/IAI.61.4.1222-1231.1993","article-title":"Oral vaccination of calves with an aromatic-dependent Salmonella dublin (O9, 12) hybrid expressing O4, 12 protects against S.dublin (O9, 12) but not against Salmonella typhimurium (O4, 5, 12","volume":"61","author":"Segall","year":"1993","journal-title":"Infect Immun"},{"key":"H80-3","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1073\/pnas.93.6.2593","article-title":"Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium","volume":"93","author":"Shea","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"H81-3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1348-0421.1999.tb02439.x","article-title":"Protective efficacy and immunogenicity of Vi-porin conjugate against Salmonella typhi","volume":"43","author":"Singh","year":"1999","journal-title":"Microbiol Immunol"},{"key":"H82-3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1128\/IAI.65.4.1566-1569.1997","article-title":"Salmonella typhimurium aroA , htrA , and aroD htrA mutants cause progressive infections in athymic ( nu \/ nu ) BALB\/c mice","volume":"65","author":"Sinha","year":"1997","journal-title":"Infect Immun"},{"key":"H83-3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0076-6879(94)35164-3","article-title":"In vivo expression technology for selection of bacterial genes specifically induced in host tissues","volume":"235","author":"Slauch","year":"1994","journal-title":"Methods Enzymol"},{"key":"H84-3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1128\/IAI.61.2.610-618.1993","article-title":"Oral immunization of mice and swine with an attenuated Salmonella choleraesuis [\u0394 cya-12 \u0394( crp\u2013cdt )19] mutant containing a recombinant plasmid","volume":"61","author":"Stabel","year":"1993","journal-title":"Infect Immun"},{"key":"H85-3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1128\/IAI.25.3.863-872.1979","article-title":"Artificial Salmonella vaccines: O-antigenic oligosaccharide-protein conjugates induce protection against infection with Salmonella typhimurium","volume":"25","author":"Svenson","year":"1979","journal-title":"Infect Immun"},{"key":"H86-3","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1128\/IAI.68.11.6311-6320.2000","article-title":"Salmonella enterica serovar Typhimurium-induced maturation of bone marrow-derived dendritic cells","volume":"68","author":"Svensson","year":"2000","journal-title":"Infect Immun"},{"key":"H87-3","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/infdis\/170.6.1508","article-title":"Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi","volume":"170","author":"Sztein","year":"1994","journal-title":"J Infect Dis"},{"key":"H88-3","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.4049\/jimmunol.155.8.3987","article-title":"Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans","volume":"155","author":"Sztein","year":"1995","journal-title":"J Immunol"},{"key":"H89-3","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1084\/jem.166.5.1510","article-title":"Vi capsular polysaccharide-protein conjugates for prevention of typhoid fever.Preparation, characterization, and immunogenicity in laboratory animals","volume":"166","author":"Szu","year":"1987","journal-title":"J Exp Med"},{"key":"H90-3","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1128\/IAI.57.12.3823-3827.1989","article-title":"Comparative immunogenicities of Vi polysaccharide-protein conjugates composed of cholera toxin or its B subunit as a carrier bound to high- or lower-molecular-weight Vi","volume":"57","author":"Szu","year":"1989","journal-title":"Infect Immun"},{"key":"H91-3","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1128\/IAI.66.7.3208-3217.1998","article-title":"The Salmonella typhimurium AhpC polypeptide is not essential for virulence in BALB\/c mice but is recognized as an antigen during infection","volume":"66","author":"Taylor","year":"1998","journal-title":"Infect Immun"},{"key":"H92-3","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/intimm\/5.11.1431","article-title":"Immunization with live versus killed Salmonella typhimurium leads to the generation of an IFN-gamma-dominant versus an IL-4-dominant immune response","volume":"5","author":"Thatte","year":"1993","journal-title":"Int Immunol"},{"key":"H93-3","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.147.9.3161","article-title":"The involvement of tumor necrosis factor in immunity to Salmonella infection","volume":"147","author":"Tite","year":"1991","journal-title":"J Immunol"},{"key":"H94-3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0140-6736(90)93250-S","article-title":"Epidemiology of foodborne illness: North America","volume":"336","author":"Todd","year":"1990","journal-title":"Lancet"},{"key":"H95-3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1128\/IAI.55.3.822-824.1987","article-title":"An outer membrane protein (porin) as an eliciting antigen for delayed-type hypersensitivity in murine salmonellosis","volume":"55","author":"Udhayakumar","year":"1987","journal-title":"Infect Immun"},{"key":"H96-3","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/44593","article-title":"Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes","volume":"401","author":"Vazquez-Torres","year":"1999","journal-title":"Nature"},{"key":"H97-3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.287.5458.1655","article-title":"Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase","volume":"287","author":"Vazquez-Torres","year":"2000","journal-title":"Science"},{"key":"H98-3","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1073\/pnas.041618998","article-title":"Defective localization of the NADPH phagocyte oxidase to Salmonella -containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages","volume":"98","author":"Vazquez-Torres","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"H99-3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0092-8674(93)90135-D","article-title":"Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg","volume":"73","author":"Vidal","year":"1993","journal-title":"Cell"},{"key":"H100-3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/icb.1990.41","article-title":"Identification of antigens which stimulate T lymphocytes of Salmonella enteritidis 11RX immunized mice","volume":"68","author":"Vordermeier","year":"1990a","journal-title":"Immunol Cell Biol"},{"key":"H101-3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/icb.1990.42","article-title":"Partial purification and characterization of low molecular weight antigens of Salmonella enteritidis 11RX","volume":"68","author":"Vordermeier","year":"1990b","journal-title":"Immunol Cell Biol"},{"key":"H102-3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/icb.1990.23","article-title":"Presentation of Salmonella antigens by peritoneal cells of normal and Salmonella -infected mice","volume":"68","author":"Vordermeier","year":"1990","journal-title":"Immunol Cell Biol"},{"key":"H103-3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1128\/IAI.70.2.551-557.2002","article-title":"Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection","volume":"70","author":"Warren","year":"2002","journal-title":"Infect Immun"},{"key":"H104-3","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1128\/IAI.60.11.4679-4686.1992","article-title":"Protection of mice against Salmonella typhimurium with an O-specific polysaccharide-protein conjugate vaccine","volume":"60","author":"Watson","year":"1992","journal-title":"Infect Immun"},{"key":"H105-3","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1128\/IAI.65.6.2306-2312.1997","article-title":"Role of \u03b1\u03b2 and \u03b3\u03b4 T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes","volume":"65","author":"Weintraub","year":"1997","journal-title":"Infect Immun"},{"key":"H106-3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0264-410X(93)90256-W","article-title":"Correlation of antibody titres induced by vaccination with protection in mouse typhoid","volume":"11","author":"Xu","year":"1993","journal-title":"Vaccine"},{"key":"H107-3","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1128\/IAI.69.9.5726-5735.2001","article-title":"In vivo activation of dendritic cells and T cells during Salmonella enterica serovar Typhimurium infection","volume":"69","author":"Yrlid","year":"2001","journal-title":"Infect Immun"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.05173-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T08:31:19Z","timestamp":1682497879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.05173-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,1]]},"references-count":107,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.05173-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,1]]}}}