{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:45:37Z","timestamp":1761630337439},"reference-count":44,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5,1]]},"abstract":"<jats:p>A diabetic renal transplant recipient with cellulitis caused by <jats:italic>Cryptococcus neoformans<\/jats:italic>, serotype A, is described. The diagnosis was based on the demonstration of capsulated, budding yeast cells in the aspirated material and tissue from the cellulitic lesion and isolation of the aetiological agent in culture. The isolate formed well-developed capsules in the brain tissue of experimentally infected mice and produced cherry-brown colonies on niger seed medium. The patient's serum was positive for cryptococcal antigen (titre 1 : 4) with no other evidence of systemic infection. He was successfully treated with AmBisome, followed by fluconazole, resulting in the complete resolution of cellulitis and disappearance of the cryptococcal antigen. This report underscores the fact that patients with cutaneous cryptococcosis should be thoroughly evaluated, as it may be the first manifestation of a systemic disease. Prompt diagnosis and treatment are important to improve survival.<\/jats:p>","DOI":"10.1099\/jmm.0.05362-0","type":"journal-article","created":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T22:35:45Z","timestamp":1082414145000},"page":"445-449","source":"Crossref","is-referenced-by-count":29,"title":["Cutaneous cryptococcosis in a diabetic renal transplant recipient"],"prefix":"10.1099","volume":"53","author":[{"given":"R. K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mubarak Al-Kabeer Hospital, Ministry of Public Health, Kuwait 2,3Departments of Microbiology2 and Medicine3, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Mubarak Al-Kabeer Hospital, Ministry of Public Health, Kuwait 2,3Departments of Microbiology2 and Medicine3, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.N.","family":"Nampoory","sequence":"additional","affiliation":[{"name":"Mubarak Al-Kabeer Hospital, Ministry of Public Health, Kuwait 2,3Departments of Microbiology2 and Medicine3, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Mikhail","sequence":"additional","affiliation":[{"name":"Mubarak Al-Kabeer Hospital, Ministry of Public Health, Kuwait 2,3Departments of Microbiology2 and Medicine3, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. V.","family":"Johny","sequence":"additional","affiliation":[{"name":"Mubarak Al-Kabeer Hospital, Ministry of Public Health, Kuwait 2,3Departments of Microbiology2 and Medicine3, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"H1-15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-4362.1975.tb00149.x","article-title":"Primary cutaneous cryptococcosis in Egypt","volume":"14","author":"Abdel-Fattah","year":"1975","journal-title":"Int J Dermatol"},{"key":"H2-15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF02930967","article-title":"Characterization of Cryptococcus neoformans var. neoformans serotype A and A\/D in samples from Egypt","volume":"48","author":"Abdel-Salam","year":"2003","journal-title":"Folia Microbiol"},{"key":"H3-15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/02724936.1990.11747452","article-title":"Cryptococcal meningitis in a child with systemic lupus erythematosus","volume":"10","author":"al-Rasheed","year":"1990","journal-title":"Ann Trop Paediatr"},{"key":"H4-15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/clinids\/14.3.666","article-title":"Cryptococcal disease presenting as cellulitis","volume":"14","author":"Anderson","year":"1992","journal-title":"Clin Infect Dis"},{"key":"H5-15","first-page":"515","article-title":"Cutaneous cryptococcosis","volume":"69","author":"Birkett","year":"1976","journal-title":"Proc R Soc Med"},{"key":"H6-15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0190-9622(84)80013-4","article-title":"Disseminated cryptococcosis presenting as herpetiform lesions in a homosexual man with acquired immunodeficiency syndrome","volume":"10","author":"Borton","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"H7-15","first-page":"236","article-title":"Primary pulmonary cryptococcosis","volume":"94","author":"Campbell","year":"1996","journal-title":"Am Rev Respir Dis"},{"key":"H8-15","doi-asserted-by":"crossref","DOI":"10.1128\/9781555818241","volume-title":"Cryptococcus neoformans","author":"Casadevall","year":"1998"},{"key":"H9-15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1086\/313992","article-title":"& 7 other authors","volume":"31","author":"Chen","year":"2000","journal-title":"Clin Infect Dis"},{"key":"H10-15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/1369378031000137224","article-title":"Primary cutaneous cryptococcosis in immunocompetent and immunocompromised hosts","volume":"41","author":"Christianson","year":"2003","journal-title":"Med Mycol"},{"key":"H11-15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/infdis\/158.4.897","article-title":"Cutaneous cryptococcosis mimicking molluscum contagiosum in a patient with AIDS","volume":"158","author":"Concus","year":"1988","journal-title":"J Infect Dis"},{"key":"H12-15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/archderm.1958.01560020062007","article-title":"Cryptococcosis case with unusual skin lesions and favourable response to amphotericin B therapy","volume":"77","author":"Crounse","year":"1958","journal-title":"Arch Dermatol"},{"key":"H13-15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/AAC.44.1.143-149.2000","article-title":"& 7 other authors","volume":"44","author":"Cruz","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"H14-15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/PL00011265","article-title":"Flucytosine primary resistance in Candida species and Cryptococcus neoformans","volume":"20","author":"Cuenca-Estrella","year":"2001","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"H15-15","first-page":"1980","article-title":"Cryptococcus neoformans . 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