{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T22:30:30Z","timestamp":1723761030093},"reference-count":30,"publisher":"Microbiology Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:p><jats:italic>Mycobacterium bovis<\/jats:italic>Bacille Calmette\u2013Gu\u00e9rin (BCG) is the current vaccine used against<jats:italic>Mycobacterium tuberculosis<\/jats:italic>(MTB) infection. However, exposure to environmental pathogens, such as<jats:italic>Mycobacterium avium<\/jats:italic>, interferes with the immune response induced by BCG vaccination. How<jats:italic>M. avium<\/jats:italic>affects the efficiency of BCG is unclear. In this study, BCG-vaccinated mice pre-treated with<jats:italic>M. avium<\/jats:italic>-derived lipids (MALs) showed a higher mycobacterial load and increased infiltration of inflammatory cells compared to control mice treated with<jats:italic>Escherichia coli<\/jats:italic>-derived lipids (ELs). Unexpectedly, there were no changes in cell proliferation or IFN-\u03b3 levels in spleen cells stimulated with protein purified derivatives (PPD) or heat-inactivated BCG in MALs-treated mice. However, pre-treatment with MALs decreased the bactericidal effect as well as the production of TNF-\u03b1 and nitric oxide (NO) in murine macrophages from BCG-vaccinated mice stimulated with IFN-\u03b3. These results suggest that MAL pre-treatment dampens the immune response against MTB and that this dampening is associated with a decreased response to IFN-\u03b3 stimulation in murine macrophages. T-lymphocyte responses, however, were unaffected.<\/jats:p>","DOI":"10.1099\/jmm.0.056283-0","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T04:32:11Z","timestamp":1365741131000},"page":"980-987","source":"Crossref","is-referenced-by-count":3,"title":["Pre-treatment with Mycobacterium avium-derived lipids reduces the macrophage response to interferon \u03b3 in BCG-vaccinated mice"],"prefix":"10.1099","volume":"62","author":[{"given":"Daqing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 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