{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:04:52Z","timestamp":1761581092802},"reference-count":38,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:p>\n                  <jats:italic>Pneumocystis jirovecii<\/jats:italic> causes pneumonia, a severe opportunistic infection in immunosuppressed patients that has both person-to-person airborne transmission and environmental transmission as important routes of infection. An increasing incidence of <jats:italic>P. jirovecii<\/jats:italic> in Northern Ireland prompted a detailed epidemiological and molecular review that included enhanced surveillance on all lower respiratory specimens. Genotyping of these <jats:italic>P. jirovecii<\/jats:italic> positive specimens was undertaken using multiple locus sequence typing (MLST) targeting known variable regions of the <jats:italic>P. jirovecii<\/jats:italic> genome. Multiple circulating types were found among all patient risk categories. However, a predominance of one MLST type was found in a <jats:italic>P. jirovecii<\/jats:italic> outbreak amongst the renal transplant population. Our results demonstrate the diversity of <jats:italic>P. jirovecii<\/jats:italic> strains amongst the local immunosuppressed cohort and highlight the importance of genotyping in the investigation of common sources of <jats:italic>P. jirovecii<\/jats:italic> amongst immunosuppressed patients.<\/jats:p>","DOI":"10.1099\/jmm.0.057794-0","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T12:17:58Z","timestamp":1369311478000},"page":"1170-1174","source":"Crossref","is-referenced-by-count":13,"title":["Pneumocystis jirovecii multilocus genotyping profiles in Northern Ireland"],"prefix":"10.1099","volume":"62","author":[{"given":"Tanya","family":"Curran","sequence":"first","affiliation":[{"name":"Regional Virus Laboratory, Microbiology Department, Kelvin Building, Royal Victoria Hospital, Belfast, Northern Ireland BT12 6BA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conall","family":"McCaughey","sequence":"additional","affiliation":[{"name":"Regional Virus Laboratory, Microbiology Department, Kelvin Building, Royal Victoria Hospital, Belfast, Northern Ireland BT12 6BA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter V.","family":"Coyle","sequence":"additional","affiliation":[{"name":"Regional Virus Laboratory, Microbiology Department, Kelvin Building, Royal Victoria Hospital, Belfast, Northern Ireland BT12 6BA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.10.027"},{"key":"r2","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1128\/JCM.35.10.2511-2513.1997","article-title":"Detection of Pneumocystis carinii DNA in air samples: likely environmental risk to susceptible persons","volume":"35","author":"Bartlett","year":"1997","journal-title":"J Clin Microbiol"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.3201\/eid0603.000306"},{"key":"r4","article-title":"HIV\/AIDS Surveillance Report, Vol. 19","year":"2007"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1092-2"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.043984-0"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1086\/513198"},{"key":"r8","first-page":"673","article-title":"Outbreaks and clustering of Pneumocystis pneumonia in kidney transplant recipients: a systematic review","volume":"49","author":"de Boer","year":"2011","journal-title":"Med Mycol"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01944.x"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00447.x"},{"key":"r11","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1128\/JCM.35.12.3086-3091.1997","article-title":"Typing of Pneumocystis carinii f. sp. hominis by single-strand conformation polymorphism of four genomic regions","volume":"35","author":"Hauser","year":"1997","journal-title":"J Clin Microbiol"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200103090-00004"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1996.tb04971.x"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1086\/313843"},{"key":"r15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/JCM.35.2.383-387.1997","article-title":"Biodiversity of Pneumocystis carinii hominis: typing with different DNA regions","volume":"35","author":"Latouche","year":"1997","journal-title":"J Clin Microbiol"},{"key":"r16","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1128\/JCM.32.12.2904-2912.1994","article-title":"Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes","volume":"32","author":"Lu","year":"1994","journal-title":"J Clin Microbiol"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.75"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr444"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.11.3877-3882.2001"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1186\/cc6806"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00013-12"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-094OC"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1080\/15412550701817656"},{"key":"r24","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1128\/JCM.36.6.1737-1740.1998","article-title":"Identification of Pneumocystis carinii f. sp. hominis gene sequences in filtered air in hospital environments","volume":"36","author":"Olsson","year":"1998","journal-title":"J Clin Microbiol"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1089\/108729103322108139"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.3201\/eid1010.040453"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0758-5"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02016-07"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.10.4384"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032588"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1621"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir329"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.1.141"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.8.2995-2998.2001"},{"key":"r35","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1128\/JCM.34.7.1754-1759.1996","article-title":"DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora","volume":"34","author":"Wakefield","year":"1996","journal-title":"J Clin Microbiol"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001058"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6688"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181aed389"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.057794-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T03:17:33Z","timestamp":1601608653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.057794-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.057794-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}