{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:41:36Z","timestamp":1766428896106},"reference-count":21,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:p>We investigated changes in serotypes and antimicrobial susceptibilities among 386 isolates of invasive <jats:italic>Streptococcus pneumoniae<\/jats:italic> collected from numerous hospitals in Korea from 1996 to 2008. Serotypes 19F (9.8\u200a%), 23F (8.3\u200a%), 19A (7.8\u200a%), 6A (7.5\u200a%), 3 (7.3\u200a%), 9V (6.5\u200a%), 6B (6.2\u200a%), 14 (4.9\u200a%), 1 (3.9\u200a%), 11A (3.9\u200a%) and 4 (3.1\u200a%) represented 69.2\u200a% of all isolates. While the overall proportion of PCV7 serotypes was stable over time, we observed modest decreases in children &lt;5 years old and in adults \u226565 years old between 1996\u20131999 and 2007\u20132008. An increased prevalence of non-PCV7 serotypes in these age groups was primarily attributable to an increase in serotypes 3, 6A and 19A. Most invasive <jats:italic>S. pneumoniae<\/jats:italic> isolates showed high resistance rates to erythromycin (74.9\u200a%), tetracycline (71.1\u200a%) and clindamycin (61.7\u200a%). Between 1996\u20132003 and 2004\u20132008, non-susceptibility rates to cefotaxime and multi-drugs (three or more classes) in PCV7 serotypes showed a declining trend, while in non-PCV7 serotypes there was an increasing trend. Non-PCV7 serotypes 6A and 19A, which mostly exhibited multidrug-resistant phenotypes (69.0\u200a% and 76.7\u200a% respectively), increased between 1996\u20132003 and 2004\u20132008. Although PCV7 was introduced in Korea in November 2003, pneumococcal vaccination has not been included in the national child vaccination programme. Our results provide details of serotype occurrence that will be useful when adoption of universal pneumococcal vaccination in Korea is being considered.<\/jats:p>","DOI":"10.1099\/jmm.0.058164-0","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T03:59:31Z","timestamp":1368071971000},"page":"1204-1210","source":"Crossref","is-referenced-by-count":25,"title":["Changes in serotype prevalence and antimicrobial resistance among invasive Streptococcus pneumoniae isolates in Korea, 1996\u20132008"],"prefix":"10.1099","volume":"62","author":[{"given":"Sungkyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, 187, Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South 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Prevention, 187, Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeonho","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, 187, Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46530-0"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1402.070807"},{"key":"r3","article-title":"Performance Standards for Antimicrobial Susceptibility Testing: 16th Informational Supplement 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