{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:08:31Z","timestamp":1758636511756},"reference-count":19,"publisher":"Microbiology Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:p>Specimens from men with acute non-gonococcal urethritis were tested to determine their microbial content and then given intra-urethrally to male chimpanzees. Two animals received ureaplasmas only and one became infected. The second did so when given a different strain. Both developed a polymorphonuclear leukocyte (PMNL) response. Two chimpanzees received a mixture of ureaplasmas and<jats:italic>Chlamydia trachomatis<\/jats:italic>and there was a suggestion that the ureaplasmas delayed or suppressed the chlamydial response. The latter, that is urethral infection with a pronounced PMNL response, was most clearly seen in a chimpanzee given<jats:italic>C. trachomatis<\/jats:italic>only. No inflammation was detected in two chimpanzees acting as controls. Three of five chimpanzees given ureaplasmas genitally, and one that had them endogenously, had them transiently in the oropharynx about 2 weeks later. The occurrence of ureaplasmas in the conjunctiva of three chimpanzees inoculated at this site was also transient and without inflammation. The possibility that<jats:italic>Mycoplasma genitalium<\/jats:italic>might have been in the inocula and caused urethral inflammation was discounted largely because no animal had antibody to this mycoplasma.<\/jats:p>","DOI":"10.1099\/jmm.0.058446-0","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T04:41:54Z","timestamp":1375332114000},"page":"1609-1613","source":"Crossref","is-referenced-by-count":3,"title":["Urethral inflammation in male chimpanzees caused by ureaplasmas and Chlamydia trachomatis"],"prefix":"10.1099","volume":"62","author":[{"given":"David","family":"Taylor-Robinson","sequence":"first","affiliation":[{"name":"Division of Sexually Transmitted Diseases, Medical Research Council's Clinical Research Centre, Harrow, Middlesex, 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