{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:33:59Z","timestamp":1778884439538,"version":"3.51.4"},"reference-count":22,"publisher":"Microbiology Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:p>The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of 12 antibiotics against 3074 <jats:italic>E. coli<\/jats:italic> and 1025 <jats:italic>K. pneumoniae<\/jats:italic> from 23 centres located in 16 cities were determined by the broth microdilution method. During the 10 year study period, ertapenem, imipenem, amikacin and piperacillin-tazobactam retained high and stable activity against <jats:italic>E. coli<\/jats:italic> and <jats:italic>K. pneumoniae<\/jats:italic> isolates regardless of whether their source was HA or CA and regardless of their extended-spectrum beta-lactamase (ESBL) production. However, the susceptibility of <jats:italic>E. coli<\/jats:italic> to cephalosporins and ampicillin-sulbactam decreased dramatically during the 10 years, especially for the CA isolates. Fluoroquinolones showed low activity against <jats:italic>E. coli<\/jats:italic>. During the whole study period, the ESBL rates for <jats:italic>E. coli<\/jats:italic> isolates from IAIs increased from 36.1\u200a% in 2002\u20132003 to 68.1\u200a% in 2010\u20132011 (<jats:italic>P<\/jats:italic>&lt;0.001). Correspondingly, the ESBL rates in HA isolates increased from 52.2\u200a% in 2002\u20132003 to 70.0\u200a% in 2010\u20132011 (<jats:italic>P<\/jats:italic>\u200a=\u200a0.001), and in CA isolates from 19.1\u200a% in 2002\u20132003 to 61.6\u200a% in 2010\u20132011 (<jats:italic>P<\/jats:italic>&lt;0.001). The ESBL-positive rate in <jats:italic>K. pneumoniae<\/jats:italic> remained between 30.1 and 39.3\u200a% of the total isolates with no significant change during the 10 years. In conclusion, carbapenems retained the highest susceptibility rates against HA and CA <jats:italic>E. coli<\/jats:italic> and <jats:italic>K. pneumoniae<\/jats:italic>. High prevalence of ESBL in HA <jats:italic>E. coli<\/jats:italic> and fast-growing resistance in CA <jats:italic>E. coli<\/jats:italic> severely limit the empirical use of the third- and fourth-generation cephalosporins in the therapy of IAIs.<\/jats:p>","DOI":"10.1099\/jmm.0.059816-0","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T04:57:58Z","timestamp":1370494678000},"page":"1343-1349","source":"Crossref","is-referenced-by-count":35,"title":["A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China"],"prefix":"10.1099","volume":"62","author":[{"given":"Qiwen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, 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