{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:31:20Z","timestamp":1791397880811,"version":"4.3.3"},"reference-count":20,"publisher":"Microbiology Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:p>Rosacea is a chronic inflammatory condition that affects the skin of the face and the eyes. The aetiology of rosacea is not clearly established but increasing evidence suggests a potential role for bacteria in the induction of the condition. A role for <jats:italic>Bacillus oleronius<\/jats:italic>, originally isolated from within a <jats:italic>Demodex folliculorum<\/jats:italic> mite, in the aetiology of the condition has been suggested. The aim of the study was to determine whether a correlation existed between the level of sebum and the density of <jats:italic>D. folliculorum<\/jats:italic> in the skin of erythematotelangiectatic rosacea patients, and the reactivity of these patients\u2019 sera to proteins of <jats:italic>B. oleronius<\/jats:italic>. Serum reactivity to the 62 and 83 kDa <jats:italic>B. oleronius<\/jats:italic> proteins was found in 82.6\u200a% (62\/75) of the rosacea patients and in 26.9\u200a% (14\/52) of controls (<jats:italic>P<\/jats:italic>\u200a=\u200a0.0016). In the group of rosacea patients whose sera reacted to <jats:italic>B. oleronius<\/jats:italic> proteins, the level of sebum was statistically lower than in controls (<jats:italic>P<\/jats:italic>\u200a=\u200a0.01). The density of <jats:italic>D. folliculorum<\/jats:italic> on the face of <jats:italic>Bacillus<\/jats:italic> positive rosacea patients was statistically higher than controls (<jats:italic>P<\/jats:italic>\u200a=\u200a0.0001). Rosacea patients demonstrated increased <jats:italic>Demodex<\/jats:italic> populations on their faces and reduced sebum levels. Their sera also showed reactivity to <jats:italic>B. oleronius<\/jats:italic> proteins, suggesting a potential role for this bacterium in the aetiology of rosacea.<\/jats:p>","DOI":"10.1099\/jmm.0.065136-0","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T04:48:57Z","timestamp":1384836537000},"page":"258-262","source":"Crossref","is-referenced-by-count":35,"title":["Correlation between serum reactivity to Demodex-associated Bacillus oleronius proteins, and altered sebum levels and Demodex populations in erythematotelangiectatic rosacea patients"],"prefix":"10.1099","volume":"63","author":[{"given":"Stanis\u0142aw","family":"Jarmuda","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology, University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard","family":"\u017baba","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Jakubowicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashling","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Szkaradkiewicz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Biology, National University of Ireland, Maynooth, Co. 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