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Patients then underwent secondary treatment with a variety of antimicrobial agents but remained symptomatic with <jats:italic>Blastocystis<\/jats:italic> spp. still present in faeces. Sequencing of the SSU rDNA was completed on all isolates and four subtypes were identified in this group: ST1, ST3, ST4 and ST5. This study highlights the lack of efficacy of several commonly used antimicrobial regimens in the treatment of <jats:italic>Blastocystis<\/jats:italic> and the chronic nature of some infections. It also demonstrates the need for further research into treatment options for <jats:italic>Blastocystis<\/jats:italic> infection.<\/jats:p>","DOI":"10.1099\/jmm.0.065508-0","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T05:10:14Z","timestamp":1384578614000},"page":"252-257","source":"Crossref","is-referenced-by-count":42,"title":["Treatment failure in patients with chronic Blastocystis infection"],"prefix":"10.1099","volume":"63","author":[{"given":"Tamalee","family":"Roberts","sequence":"first","affiliation":[{"name":"i3 Institute, School of Medical and Molecular Sciences, University of Technology, Sydney, Ultimo, NSW, Australia"},{"name":"Department of Microbiology, SydPath, St Vincent\u2019s Hospital, Victoria St., Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ellis","sequence":"additional","affiliation":[{"name":"i3 Institute, School of Medical and Molecular Sciences, University of Technology, Sydney, Ultimo, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Harkness","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SydPath, St Vincent\u2019s Hospital, Victoria St., Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Marriott","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SydPath, St Vincent\u2019s Hospital, Victoria St., Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SydPath, St Vincent\u2019s Hospital, Victoria St., Darlinghurst, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.04.037"},{"key":"r2","first-page":"149","article-title":"Urticaria by Blastocystis hominis. 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