{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:20:08Z","timestamp":1790432408259,"version":"4.1.0"},"reference-count":26,"publisher":"Microbiology Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:p>We describe the case of a 16-year-old German male expatriate from Ghana who presented with obstipation, dysuria, dysaesthesia of the gluteal region and the lower limbs, bilateral plantar hypaesthesia and paraesthesia without pareses. A serum\u2013cerebrospinal fluid (CSF) <jats:italic>Schistosoma<\/jats:italic> spp. specific antibody specificity index of 3.1 was considered highly suggestive of intrathecal synthesis of anti-<jats:italic>Schistosoma<\/jats:italic> spp. specific antibodies, although standardization of this procedure has not previously been described. Diagnosis was confirmed by detection of <jats:italic>Schistosoma<\/jats:italic> DNA in CSF by semi-quantitative real-time PCR at 100-fold concentration compared with serum. Accordingly the two diagnostic procedures, which have not previously been applied for routine diagnosis, appear to be useful for the diagnosis of neuroschistosomiasis. Clinical symptoms resolved following anthelmintic and anti-inflammatory therapy.<\/jats:p>","DOI":"10.1099\/jmm.0.066142-0","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T04:18:03Z","timestamp":1384402683000},"page":"309-312","source":"Crossref","is-referenced-by-count":22,"title":["Diagnosis of neuroschistosomiasis by antibody specificity index and semi-quantitative real-time PCR from cerebrospinal fluid and serum"],"prefix":"10.1099","volume":"63","author":[{"given":"Georg","family":"H\u00e4rter","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Immunology, Comprehensive Infectious Diseases Centre Ulm and Clinic of Internal Medicine III, University Hospital Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen","family":"Frickmann","sequence":"additional","affiliation":[{"name":"Institute for Microbiology, Virology and Hygiene, University Hospital Rostock, 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