{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:42:23Z","timestamp":1762004543314},"reference-count":17,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"Multilocus sequence typing and in vitro<\/jats:italic> antimicrobial susceptibility testing were performed for three community-onset New Delhi metallo-\u03b2-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae<\/jats:italic> isolates from Korea. The genetic structure surrounding the bla<\/jats:italic>\n NDM-1<\/jats:sub> gene was determined in bla<\/jats:italic>\n NDM-1<\/jats:sub>-harbouring plasmids. Three NDM-1-producing K. pneumoniae<\/jats:italic> isolates were found to belong to the same clone (sequence type 340). Each of these isolates showed the same genetic structure surrounding the bla<\/jats:italic>\n NDM-1<\/jats:sub> gene. The genes bla<\/jats:italic>\n NDM-1<\/jats:sub>, ble<\/jats:italic>\n MBL<\/jats:sub>, trpF<\/jats:italic> and dsbC<\/jats:italic> were flanked by two intact insertion sequences, ISAba125<\/jats:italic> and IS26<\/jats:italic>, which may promote horizontal gene transfer. The bla<\/jats:italic>\n NDM-1<\/jats:sub>-harbouring plasmids conferred antimicrobial resistance to carbapenems, cephalosporins, aminoglycosides and aztreonam in transconjugants. It can be speculated that either the entire bla<\/jats:italic>\n NDM-1<\/jats:sub>-harbouring plasmids or just the part of the plasmid containing the bla<\/jats:italic>\n NDM-1<\/jats:sub> gene may have transferred between K. pneumoniae<\/jats:italic> and Escherichia<\/jats:italic> \n coli<\/jats:italic>. Following the transfer, the isolate disseminated throughout Korea. This study suggests the need for monitoring the dissemination of NDM-1-producing isolates across countries or continents due to their potential transferability via ISAba125-<\/jats:italic> and IS26<\/jats:italic>-associated transposons.<\/jats:p>","DOI":"10.1099\/jmm.0.067744-0","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T03:21:44Z","timestamp":1383189704000},"page":"86-89","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics of community-onset NDM-1-producing Klebsiella pneumoniae isolates"],"prefix":"10.1099","volume":"63","author":[{"given":"So Yeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Young","family":"Rhee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Dankook University, Cheonan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yop","family":"Shin","sequence":"additional","affiliation":[{"name":"Korea Medical Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan Soo","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.11.025"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.12.006"},{"key":"r3","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2013"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.4178-4182.2005"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017989"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06855-11"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.04.006"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066666"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.09.005"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.06.013"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq428"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks143"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00642-11"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks114"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70059-7"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00774-09"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.067744-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T08:17:36Z","timestamp":1601972256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.067744-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.067744-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}