{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:54:30Z","timestamp":1790463270302,"version":"4.1.0"},"reference-count":21,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:p>Human enterovirus 68 (HEV-68) is an enterovirus associated with respiratory illness. In China, no information about HEV-68 is available for children yet. This study aimed to investigate the presence of HEV-68 in mainland China between 2009 and 2012 and to explore the migration events of HEV-68 across the world. Among 1565 samples tested from children, 41 (2.6\u200a%) were positive for HEV and 223 (14.3\u200a%) for human rhinovirus (HRV). Seven (17.1\u200a%) of 41 HEVs were HEV-68. Two HEV-68- and five HRV-positive samples were detected in 585 adult samples. HEV-68 is the predominant type of enterovirus in children with acute respiratory tract infection (ARTI), followed by HEV-71 and coxsackievirus A6. Three HEV-68-infected children presented with severe pneumonia and one presented with a severe asthma attack. The viruses were attributed to two novel distinct sublineages of HEV-68 based on phylogenetic analysis of partial VP1 gene sequences. Migration events analysis showed that the USA and the Netherlands were possible geographical sources of HEV-68, from where three strains migrated to China. In conclusion, HEV-68 may play a predominant role among the enteroviruses associated with ARTI in children. Additional surveillance is needed to clarify the reason why HEV-68 causes such a wide spectrum of disease, from asymptomatic to severe respiratory disease and even death.<\/jats:p>","DOI":"10.1099\/jmm.0.068247-0","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T03:58:49Z","timestamp":1386647929000},"page":"408-414","source":"Crossref","is-referenced-by-count":46,"title":["Detection of enterovirus 68 as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China"],"prefix":"10.1099","volume":"63","author":[{"given":"Qing-Bin","family":"Lu","sequence":"first","affiliation":[{"name":"School of Public Health, Peking University, Beijing, 100191, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, PR 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Institute of Microbiology and Epidemiology, Beijing, 100071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Chongqing Medical University, Chongqing, 400014, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Chongqing Medical University, Chongqing, 400014, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Tang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Shandong University, Jinan, 250012, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, PR 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