{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:43:12Z","timestamp":1787690592844,"version":"build-2784847793"},"reference-count":34,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:p>Few studies have described how an expanding elderly population influences the burden of antimicrobial resistance in micro-organisms. This study aimed to investigate trends in age-stratified extended-spectrum \u03b2-lactamase (ESBL)-positive <jats:italic>Escherichia coli<\/jats:italic> metrics in relation to an ageing population. The antimicrobial resistance database of <jats:italic>E. coli<\/jats:italic> from a healthcare region in Hong Kong from 2003 to 2012 was retrospectively reviewed. Future trends in age-stratified ESBL metrics were predicted up to 2022. Susceptibility results of clinical <jats:italic>E. coli<\/jats:italic> isolates from patients aged 0\u201374 years (<jats:italic>n<\/jats:italic>\u200a=\u200a17\u200a853) and aged \u226575 years (<jats:italic>n<\/jats:italic>\u200a=\u200a17\u200a047) were analysed. For the period 2003\u20132012, 23.7\u200a% of the hospital admissions were of patients aged \u226575 years. However, approximately half of the annual ESBL-positive <jats:italic>E. coli<\/jats:italic> isolates were recovered from patients aged \u226575 years, being 55.0\u200a% (233\/424) in 2003 and 56.0\u200a% (639\/1142) in 2012. During this period of time, the annual prevalence and cumulative incidence of ESBL-positive <jats:italic>E. coli<\/jats:italic> in patients aged \u226575 years were significantly higher than in patients aged 0\u201374 years. From 2012\u20132022, it is predicted that ESBL-positive <jats:italic>E. coli<\/jats:italic> prevalence among patients aged 0\u201374 years and \u226575 years would increase from 25.4\u200a% to 50.2\u200a% and from 30.8\u200a% to 70.0\u200a%, respectively. In 2022, the predicted ESBL-positive <jats:italic>E. coli<\/jats:italic> cumulative incidence would be 63.7 per 10\u200a000 admissions and 178.7 per 10\u200a000 admissions among patients aged 0\u201374 years and \u226575 years, respectively. In conclusion, a rapidly expanding elderly population would substantially add to the burden of ESBL.<\/jats:p>","DOI":"10.1099\/jmm.0.068270-0","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T03:06:53Z","timestamp":1397185613000},"page":"878-883","source":"Crossref","is-referenced-by-count":8,"title":["High burden of extended-spectrum \u03b2-lactamase-positive Escherichia coli in geriatric patients"],"prefix":"10.1099","volume":"63","author":[{"given":"Pak-Leung","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong Special Administrative Region, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui-Hing","family":"Chau","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Hong Kong, Hong Kong Special Administrative Region, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Kum","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong Special Administrative Region, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin-Hung","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong Special Administrative Region, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H. 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